Receptor-mediated muscle homeostasis as a target for sarcopenia therapeutics

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Receptor-mediated muscle homeostasis as a target for sarcopenia therapeutics
Jong Hyeon Yoon; Ki-Sun Kwon
Bibliographic Citation
Endocrinology and Metabolism, vol. 36, no. 3, pp. 478-490
Publication Year
Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement of multiple interconnected signaling pathways. Therefore, signaling receptors are major targets in pharmacological strategies in general. To provide a rationale for pharmacological interventions for sarcopenia, we herein describe several druggable signaling receptors based on their role in skeletal muscle homeostasis and changes in their activity with aging. A brief overview is presented of the efficacy of corresponding drug candidates under clinical trials. Strategies targeting the androgen receptor, vitamin D receptor, Insulin-like growth factor-1 receptor, and ghrelin receptor primarily focus on promoting anabolic action using natural ligands or mimetics. Strategies involving activin receptors and angiotensin receptors focus on inhibiting catabolic action. This review may help to select specific targets or combinations of targets in the future.
SarcopeniaMuscle, skeletalAgingDrug therapyReceptors, cell surfaceReceptors, cytoplasmic and nuclearSignal transductionMolecular mechanisms of pharmacological actionClinical trial
Korea Soc-Assoc-Inst
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1. Journal Articles > Journal Articles
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