Combination treatment of arazyme and soy leaf extract attenuates hyperglycemia and hepatic steatosis in high-fat diet-fed C57BL/6J mice = 고지방식이로 유도된 마우스에서 아라자임과 콩잎추출물의 병용 처리에 의한 고혈당 및 간지방증 예방 효능

Cited 1 time in scopus
Metadata Downloads
Title
Combination treatment of arazyme and soy leaf extract attenuates hyperglycemia and hepatic steatosis in high-fat diet-fed C57BL/6J mice = 고지방식이로 유도된 마우스에서 아라자임과 콩잎추출물의 병용 처리에 의한 고혈당 및 간지방증 예방 효능
Author(s)
Hwa Lee; Seona Cho; Anna Kang; D H Shin; Ho Yong ParkTae Sook Jeong
Bibliographic Citation
Life-Basel, vol. 11, no. 7, pp. 645-645
Publication Year
2021
Abstract
Arazyme and extracts of soy leaves (ESLs) are used as ingredients for functional foods; however, their combined administration has not been studied. This study assessed the combined effect of Arazyme and ESLs in high-fat-diet (HFD)-induced obese C57BL/6J mice fed 2 mg/kg Arazyme, 50 mg/kg ESLs, or a combination of 2 mg/kg Arazyme and 50 mg/kg ESLs by oral gavage for 13 weeks. Individually, Arazyme and ESLs had no effect on the HFD-induced phenotypes. The combination of Arazyme and ESLs significantly suppressed body weight gain, improved glucose and insulin tolerance, and suppressed hepatic steatosis by reducing lipid synthesis and enhancing lipid utilization gene expression. Furthermore, the combination significantly reduced HFD-induced plasma bile acid reabsorption by suppressing bile acid transporter expression, including the ATP biding cassette subfamily B member 11 (Abcb11), solute carrier family 10 member 1 (Slc10a1), Slc10a2, Slc51a, and Slc51b in the liver and gut. Moreover, the combination of Arazyme and ESLs significantly prevented HFD-induced islet compensation in the pancreas. These results suggest that the incorporation of Arazyme combined with ESLs reduces HFD-induced body weight, hyperglycemia, and hepatic steatosis by regulating liver-gut bile acid circulation in HFD-fed mice. This combination can markedly reduce treatment doses and enhance their therapeutic effects, thereby reducing therapeutic healthcare costs.
Keyword
ArazymeSoy leafDiet therapyHepatic steatosisHyperglycemiaObesity
ISSN
2075-1729
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/life11070645
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.