Angucyclines containing β-D-glucuronic acid from Streptomyces sp. KCB15JA151

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dc.contributor.authorGil Soo Kim-
dc.contributor.authorJun-Pil Jang-
dc.contributor.authorTaehoon Oh-
dc.contributor.authorMin Cheol Kwon-
dc.contributor.authorByeong San Lee-
dc.contributor.authorJung-Sook Lee-
dc.contributor.authorSung-Kyun Ko-
dc.contributor.authorYoung-Soo Hong-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorJae-Hyuk Jang-
dc.date.accessioned2021-07-10T03:30:29Z-
dc.date.available2021-07-10T03:30:29Z-
dc.date.issued2021-
dc.identifier.issn0960894X-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24474-
dc.description.abstractTwo angucyclines, pseudonocardones D (1) and E (2), were isolated from Streptomyces sp. KCB15JA151. The planar structure was elucidated by comprehensive spectroscopic analysis. The absolute configuration of the sugar unit was determined based on the basis of coupling constants, ROESY, chemical derivatization and HPLC analysis. The biological activities of compounds 1 and 2 were examined by performing a computational target prediction, which led to tests of the antiestrogenic activity. The result suggested that compound 1 might be an ERα antagonist.-
dc.publisherElsevier-
dc.titleAngucyclines containing β-D-glucuronic acid from Streptomyces sp. KCB15JA151-
dc.title.alternativeAngucyclines containing β-D-glucuronic acid from Streptomyces sp. KCB15JA151-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number0-
dc.citation.endPage128237-
dc.citation.startPage128237-
dc.citation.volume48-
dc.contributor.affiliatedAuthorGil Soo Kim-
dc.contributor.affiliatedAuthorJun-Pil Jang-
dc.contributor.affiliatedAuthorTaehoon Oh-
dc.contributor.affiliatedAuthorMin Cheol Kwon-
dc.contributor.affiliatedAuthorByeong San Lee-
dc.contributor.affiliatedAuthorJung-Sook Lee-
dc.contributor.affiliatedAuthorSung-Kyun Ko-
dc.contributor.affiliatedAuthorYoung-Soo Hong-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.alternativeName김길수-
dc.contributor.alternativeName장준필-
dc.contributor.alternativeName오태훈-
dc.contributor.alternativeName권민철-
dc.contributor.alternativeName이병산-
dc.contributor.alternativeName이정숙-
dc.contributor.alternativeName고성균-
dc.contributor.alternativeName홍영수-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeName장재혁-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 48, pp. 128237-128237-
dc.identifier.doi10.1016/j.bmcl.2021.128237-
dc.subject.keywordStreptomyces sp.-
dc.subject.keywordAngucycline-
dc.subject.keywordβ-D-Glucuronic acid-
dc.subject.localStreptomyces sp.-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
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