Necroptosis molecular mechanisms: recent findings regarding novel necroptosis regulators

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dc.contributor.authorJinho Seo-
dc.contributor.authorY W Nam-
dc.contributor.authorS Kim-
dc.contributor.authorDoo-Byoung Oh-
dc.contributor.authorJ Song-
dc.date.accessioned2021-07-10T03:30:50Z-
dc.date.available2021-07-10T03:30:50Z-
dc.date.issued2021-
dc.identifier.issn1226-3613-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24476-
dc.description.abstractNecroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes, including swelling and membrane rupture, and release damage-associated molecular patterns (DAMPs), inflammatory cytokines, and chemokines, thereby mediating extreme inflammatory responses. Studies on gene knockout or necroptosis-specific inhibitor treatment in animal models have provided extensive evidence regarding the important roles of necroptosis in inflammatory diseases. The necroptosis signaling pathway is primarily modulated by activation of receptor-interacting protein kinase 3 (RIPK3), which phosphorylates mixed-lineage kinase domain-like protein (MLKL), mediating MLKL oligomerization. In the necroptosis process, these proteins are fine-tuned by posttranslational regulation via phosphorylation, ubiquitination, glycosylation, and protein-protein interactions. Herein, we review recent findings on the molecular regulatory mechanisms of necroptosis.-
dc.publisherSpringer-Nature Pub Group-
dc.titleNecroptosis molecular mechanisms: recent findings regarding novel necroptosis regulators-
dc.title.alternativeNecroptosis molecular mechanisms: recent findings regarding novel necroptosis regulators-
dc.typeArticle-
dc.citation.titleExperimental and Molecular Medicine-
dc.citation.number6-
dc.citation.endPage1017-
dc.citation.startPage1007-
dc.citation.volume53-
dc.contributor.affiliatedAuthorJinho Seo-
dc.contributor.affiliatedAuthorDoo-Byoung Oh-
dc.contributor.alternativeName서진호-
dc.contributor.alternativeName남영우-
dc.contributor.alternativeName김성미-
dc.contributor.alternativeName오두병-
dc.contributor.alternativeName송재환-
dc.identifier.bibliographicCitationExperimental and Molecular Medicine, vol. 53, no. 6, pp. 1007-1017-
dc.identifier.doi10.1038/s12276-021-00634-7-
dc.description.journalClassY-
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Aging Convergence Research Center > 1. Journal Articles
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