DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jinho Seo | - |
dc.contributor.author | Y W Nam | - |
dc.contributor.author | S Kim | - |
dc.contributor.author | Doo-Byoung Oh | - |
dc.contributor.author | J Song | - |
dc.date.accessioned | 2021-07-10T03:30:50Z | - |
dc.date.available | 2021-07-10T03:30:50Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/24476 | - |
dc.description.abstract | Necroptosis is a form of programmed necrosis that is mediated by various cytokines and pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes, including swelling and membrane rupture, and release damage-associated molecular patterns (DAMPs), inflammatory cytokines, and chemokines, thereby mediating extreme inflammatory responses. Studies on gene knockout or necroptosis-specific inhibitor treatment in animal models have provided extensive evidence regarding the important roles of necroptosis in inflammatory diseases. The necroptosis signaling pathway is primarily modulated by activation of receptor-interacting protein kinase 3 (RIPK3), which phosphorylates mixed-lineage kinase domain-like protein (MLKL), mediating MLKL oligomerization. In the necroptosis process, these proteins are fine-tuned by posttranslational regulation via phosphorylation, ubiquitination, glycosylation, and protein-protein interactions. Herein, we review recent findings on the molecular regulatory mechanisms of necroptosis. | - |
dc.publisher | Springer-Nature Pub Group | - |
dc.title | Necroptosis molecular mechanisms: recent findings regarding novel necroptosis regulators | - |
dc.title.alternative | Necroptosis molecular mechanisms: recent findings regarding novel necroptosis regulators | - |
dc.type | Article | - |
dc.citation.title | Experimental and Molecular Medicine | - |
dc.citation.number | 6 | - |
dc.citation.endPage | 1017 | - |
dc.citation.startPage | 1007 | - |
dc.citation.volume | 53 | - |
dc.contributor.affiliatedAuthor | Jinho Seo | - |
dc.contributor.affiliatedAuthor | Doo-Byoung Oh | - |
dc.contributor.alternativeName | 서진호 | - |
dc.contributor.alternativeName | 남영우 | - |
dc.contributor.alternativeName | 김성미 | - |
dc.contributor.alternativeName | 오두병 | - |
dc.contributor.alternativeName | 송재환 | - |
dc.identifier.bibliographicCitation | Experimental and Molecular Medicine, vol. 53, no. 6, pp. 1007-1017 | - |
dc.identifier.doi | 10.1038/s12276-021-00634-7 | - |
dc.description.journalClass | Y | - |
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