Disruption of nucleocytoplasmic trafficking as a cellular senescence driver

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dc.contributor.authorJi Hwan Park-
dc.contributor.authorS J Ryu-
dc.contributor.authorB J Kim-
dc.contributor.authorH J Cho-
dc.contributor.authorC H Park-
dc.contributor.authorH J C Choi-
dc.contributor.authorE J Jang-
dc.contributor.authorE J Yang-
dc.contributor.authorJ A Hwang-
dc.contributor.authorS H Woo-
dc.contributor.authorJ H Lee-
dc.contributor.authorJ H Park-
dc.contributor.authorK M Choi-
dc.contributor.authorY Y Kwon-
dc.contributor.authorC K Lee-
dc.contributor.authorJ T Park-
dc.contributor.authorS C Cho-
dc.contributor.authorY I Lee-
dc.contributor.authorS B Lee-
dc.contributor.authorJ A Han-
dc.contributor.authorK A Cho-
dc.contributor.authorM S Kim-
dc.contributor.authorD Hwang-
dc.contributor.authorY S Lee-
dc.contributor.authorS C Park-
dc.date.accessioned2021-07-13T03:30:48Z-
dc.date.available2021-07-13T03:30:48Z-
dc.date.issued2021-
dc.identifier.issn1226-3613-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24482-
dc.description.abstractSenescent cells exhibit a reduced response to intrinsic and extrinsic stimuli. This diminished reaction may be explained by the disrupted transmission of nuclear signals. However, this hypothesis requires more evidence before it can be accepted as a mechanism of cellular senescence. A proteomic analysis of the cytoplasmic and nuclear fractions obtained from young and senescent cells revealed disruption of nucleocytoplasmic trafficking (NCT) as an essential feature of replicative senescence (RS) at the global level. Blocking NCT either chemically or genetically induced the acquisition of an RS-like senescence phenotype, named nuclear barrier-induced senescence (NBIS). A transcriptome analysis revealed that, among various types of cellular senescence, NBIS exhibited a gene expression pattern most similar to that of RS. Core proteomic and transcriptomic patterns common to both RS and NBIS included upregulation of the endocytosis-lysosome network and downregulation of NCT in senescent cells, patterns also observed in an aging yeast model. These results imply coordinated aging-dependent reduction in the transmission of extrinsic signals to the nucleus and in the nucleus-to-cytoplasm supply of proteins/RNAs. We further showed that the aging-associated decrease in Sp1 transcription factor expression was critical for the downregulation of NCT. Our results suggest that NBIS is a modality of cellular senescence that may represent the nature of physiological aging in eukaryotes.-
dc.publisherSpringer-Nature Pub Group-
dc.titleDisruption of nucleocytoplasmic trafficking as a cellular senescence driver-
dc.title.alternativeDisruption of nucleocytoplasmic trafficking as a cellular senescence driver-
dc.typeArticle-
dc.citation.titleExperimental and Molecular Medicine-
dc.citation.number6-
dc.citation.endPage1108-
dc.citation.startPage1092-
dc.citation.volume53-
dc.contributor.affiliatedAuthorJi Hwan Park-
dc.contributor.alternativeName박지환-
dc.contributor.alternativeName유성진-
dc.contributor.alternativeName김병주-
dc.contributor.alternativeName조현지-
dc.contributor.alternativeName박치현-
dc.contributor.alternativeName최효제-
dc.contributor.alternativeName장은진-
dc.contributor.alternativeName양은재-
dc.contributor.alternativeName황정아-
dc.contributor.alternativeName우승화-
dc.contributor.alternativeName이준형-
dc.contributor.alternativeName박지환-
dc.contributor.alternativeName최경미-
dc.contributor.alternativeName권영연-
dc.contributor.alternativeName이철구-
dc.contributor.alternativeName박준태-
dc.contributor.alternativeName조성춘-
dc.contributor.alternativeName이윤일-
dc.contributor.alternativeName이성배-
dc.contributor.alternativeName한정-
dc.contributor.alternativeName조경-
dc.contributor.alternativeName김민식-
dc.contributor.alternativeName황대희-
dc.contributor.alternativeName이영삼-
dc.contributor.alternativeName박상철-
dc.identifier.bibliographicCitationExperimental and Molecular Medicine, vol. 53, no. 6, pp. 1092-1108-
dc.identifier.doi10.1038/s12276-021-00643-6-
dc.description.journalClassY-
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