Chemical and biological profiles of Dendrobium in two different species, their hybrid, and gamma-irradiated mutant lines of the hybrid based on LC-QToF MS and cytotoxicity analysis

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dc.contributor.authorB Nam-
dc.contributor.authorHyun-Jae Jang-
dc.contributor.authorA R Han-
dc.contributor.authorY R Kim-
dc.contributor.authorC H Jin-
dc.contributor.authorC H Jung-
dc.contributor.authorK B Kang-
dc.contributor.authorS H Kim-
dc.contributor.authorM J Hong-
dc.contributor.authorJ B Kim-
dc.contributor.authorHyung Won Ryu-
dc.date.accessioned2021-07-15T03:30:18Z-
dc.date.available2021-07-15T03:30:18Z-
dc.date.issued2021-
dc.identifier.issn2223-7747-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24484-
dc.description.abstractThe Dendrobium species (Orchidaceae) has been cultivated as an ornamental plant as well as used in traditional medicines. In this study, the chemical profiles of Dendrobii Herba, used as herbal medicine, Dendrobium in two different species, their hybrid, and the gamma-irradiated mutant lines of the hybrid, were systematically investigated via ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QToF MS). Among the numerous peaks de-tected, 17 peaks were unambiguously identified. Gigantol (1), (1R,2R)-1,7-hydroxy-2,8-methoxy-2,3-dihydrophenanthrene-4(1H)-one (2), tristin (3), (-)-syringaresinol (4), lusianthridin (5), 2,7-dihydroxy-phenanthrene-1,4-dione (6), densiflorol B (7), denthyrsinin (8), moscatilin (9), lusianthridin dimer (10), batatasin III (11), ephemeranthol A (12), thunalbene (13), dehydroorchinol (14), dendrobine (15), shi-hunine (16), and 1,5,7-trimethoxy-2-phenanthrenol (17), were detected in Dendrobii Herba, while 1, 2, and 16 were detected in D. candidum, 1, 11, and 16 in D. nobile, and 1, 2, and 16 in the hybrid, D. nobile × candidum. The methanol extract taken of them was also examined for cytotoxicity against FaDu human hypopharynx squamous carcinoma cells, where Dendrobii Herba showed the greatest cyto-toxicity. In the untargeted metabolite analysis of 436 mutant lines of the hybrid, using UPLC-QToF MS and cytotoxicity measurements combined with multivariate analysis, two tentative flavonoids (M1 and M2) were evaluated as key markers among the analyzed metabolites, contributing to the distinction between active and inactive mutant lines. ⓒ 2021 by the authors. Licensee MDPI, Basel, Switzerland.-
dc.publisherMDPI-
dc.titleChemical and biological profiles of Dendrobium in two different species, their hybrid, and gamma-irradiated mutant lines of the hybrid based on LC-QToF MS and cytotoxicity analysis-
dc.title.alternativeChemical and biological profiles of Dendrobium in two different species, their hybrid, and gamma-irradiated mutant lines of the hybrid based on LC-QToF MS and cytotoxicity analysis-
dc.typeArticle-
dc.citation.titlePlants-Basel-
dc.citation.number7-
dc.citation.endPage1376-
dc.citation.startPage1376-
dc.citation.volume10-
dc.contributor.affiliatedAuthorHyun-Jae Jang-
dc.contributor.affiliatedAuthorHyung Won Ryu-
dc.contributor.alternativeName남보미-
dc.contributor.alternativeName장현재-
dc.contributor.alternativeName한아름-
dc.contributor.alternativeName김예람-
dc.contributor.alternativeName진창현-
dc.contributor.alternativeName정찬훈-
dc.contributor.alternativeName강교빈-
dc.contributor.alternativeName김상훈-
dc.contributor.alternativeName홍민정-
dc.contributor.alternativeName김진백-
dc.contributor.alternativeName류형원-
dc.identifier.bibliographicCitationPlants-Basel, vol. 10, no. 7, pp. 1376-1376-
dc.identifier.doi10.3390/plants10071376-
dc.subject.keywordDendrobium-
dc.subject.keywordOrchidaceae-
dc.subject.keywordD. nobile-
dc.subject.keywordD. candidum-
dc.subject.keywordD. nobile × candidum-
dc.subject.keywordGamma-irradiated mutant-
dc.subject.keywordMetabolomics-
dc.subject.keywordCytotoxicity-
dc.subject.localDendrobium-
dc.subject.localOrchidaceae-
dc.subject.localD. nobile-
dc.subject.localD. candidum-
dc.subject.localD. nobile × candidum-
dc.subject.localGamma-irradiated mutant-
dc.subject.localMetabolomics-
dc.subject.localmetabolomics-
dc.subject.localCytotoxicity-
dc.subject.localcytotoxicity-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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