Renal diffusion-weighted imaging in healthy dogs: reproducibility, test-retest repeatability, and selection of the optimal b-value combination

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Title
Renal diffusion-weighted imaging in healthy dogs: reproducibility, test-retest repeatability, and selection of the optimal b-value combination
Author(s)
S K Lee; J Lee; S Jang; E Lee; Chang-Yeop JeonKyung Seob Lim; Y B Jin; J Choi
Bibliographic Citation
Frontiers in Veterinary Science, vol. 8, pp. 641971-641971
Publication Year
2021
Abstract
Diffusion-weighted imaging (DWI) magnetic resonance imaging can evaluate alterations in the microstructure of the kidney. The purpose of this study was to assess the apparent diffusion coefficient (ADC) and the intravoxel incoherent motion model (IVIM) parameters of a normal kidney in healthy dogs, to evaluate the effect of b-value combinations on the ADC value, and the reproducibility and test-retest repeatability in monoexponential and IVIM analysis. In this experimental study, the ADC, pure diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f p) were measured from both kidneys in nine healthy beagles using nine b-values (b = 0, 50, 70, 100, 150, 200, 500, 800, and 1,000 s/mm2) twice with a 1-week interval between measurements. Interobserver and intraobserver reproducibility, and test-retest repeatability of the measurements were calculated. ADC values were measured using 10 different b-value combinations consisting of three b-values each, and were compared to the ADC obtained from nine b-values. All the ADC, D, D*, and f p values measured from the renal cortex, medulla, and the entire kidney had excellent interobserver and intraobserver reproducibility, and test-retest repeatability. The ADC obtained from a b-value combination of 0, 100, and 800 s/mm2 had the highest intraclass correlation coefficient with the ADC from nine b-values. The results of this study indicated that DWI MRI using multiple b-values is feasible for the measurement of ADC and IVIM parameters with high reproducibility and repeatability in the kidneys of healthy dogs. A combination of b = 0, 100, and 800 s/mm2 can be used for ADC measurements when multiple b-values are not available in dogs.
Keyword
CanineDiffusion-weighted magnetic resonance imagingKidneyRenal fibrosisb-value
ISSN
2297-1769
Publisher
Frontiers Media Sa
DOI
http://dx.doi.org/10.3389/fvets.2021.641971
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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