Effect of human or mouse IL-7 on the homeostasis of porcine T lymphocytes

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Title
Effect of human or mouse IL-7 on the homeostasis of porcine T lymphocytes
Author(s)
J H Hong; S H Kim; H G Kim; J H Jang; R G Son; S P Pack; Young-Ho ParkPhilyong KangKang Jin JeongJi-Su Kim; H Choi; Sun-Uk Kim; Y W Jung
Bibliographic Citation
Immune Network, vol. 21, no. 3, pp. e24-e24
Publication Year
2021
Abstract
Due to the inconsistent fluctuation of blood supply for transfusion, much attention has been paid to the development of artificial blood using other animals. Although mini-pigs are candidate animals, contamination of mini-pig T cells in artificial blood may cause a major safety concern. Therefore, it is important to analyze the cross-reactivity of IL-7, the major survival factor for T lymphocytes, between human, mouse, and mini-pig. Thus, we compared the protein sequences of IL-7 and found that porcine IL-7 was evolutionarily different from human IL-7. We also observed that when porcine T cells were cultured with either human or mouse IL-7, these cells did not increase the survival or proliferation compared to negative controls. These results suggest that porcine T cells do not recognize human or mouse IL-7 as their survival factor.
Keyword
IL-7Miniature swineGraft-versus-host diseaseT-lymphocytes
ISSN
1598-2629
DOI
http://dx.doi.org/10.4110/in.2021.21.e24
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Primate Resources Center > 1. Journal Articles
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