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- Effect of human or mouse IL-7 on the homeostasis of porcine T lymphocytes
- J H Hong; S H Kim; H G Kim; J H Jang; R G Son; S P Pack; Young-Ho Park; Philyong Kang; Kang Jin Jeong; Ji-Su Kim; H Choi; Sun-Uk Kim; Y W Jung
- Bibliographic Citation
- Immune Network, vol. 21, no. 3, pp. e24-e24
- Publication Year
- Due to the inconsistent fluctuation of blood supply for transfusion, much attention has been paid to the development of artificial blood using other animals. Although mini-pigs are candidate animals, contamination of mini-pig T cells in artificial blood may cause a major safety concern. Therefore, it is important to analyze the cross-reactivity of IL-7, the major survival factor for T lymphocytes, between human, mouse, and mini-pig. Thus, we compared the protein sequences of IL-7 and found that porcine IL-7 was evolutionarily different from human IL-7. We also observed that when porcine T cells were cultured with either human or mouse IL-7, these cells did not increase the survival or proliferation compared to negative controls. These results suggest that porcine T cells do not recognize human or mouse IL-7 as their survival factor.
- IL-7; Miniature swine; Graft-versus-host disease; T-lymphocytes
- Appears in Collections:
- Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Primate Resources Center > 1. Journal Articles
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