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- Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
- Mi Ok Lee; Su Gi Lee; Cho-Rok Jung; Ye Seul Son; Jea Woon Ryu; Kwang Bo Jung; J H Ahn; J H Oh; H A Lee; Jung Hwa Lim; Janghwan Kim; Insu Jang; Jinhyuk Choi; Jaeeun Jung; Kun Hyang Park; Byungwook Lee; Dae Soo Kim; Mi-Young Son; Hyun-Soo Cho
- Bibliographic Citation
- Nature Communications, vol. 12, pp. 4492-4492
- Publication Year
- Human pluripotent stem cell (hPSC)-derived organoids and cells have similar characteristics to human organs and tissues. Thus, in vitro human organoids and cells serve as a superior alternative to conventional cell lines and animal models in drug development and regenerative medicine. For a simple and reproducible analysis of the quality of organoids and cells to compensate for the shortcomings of existing experimental validation studies, a quantitative evaluation method should be developed. Here, using the GTEx database, we construct a quantitative calculation system to assess similarity to the human organs. To evaluate our system, we generate hPSC-derived organoids and cells, and detected organ similarity. To facilitate the access of our system by researchers, we develop a web-based user interface presenting similarity to the appropriate organs as percentages. Thus, this program could provide valuable information for the generation of high-quality organoids and cells and a strategy to guide proper lineage-oriented differentiation.
- Springer-Nature Pub Group
- Appears in Collections:
- Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
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