The short-chain fatty acid receptor GPR43 modulates YAP/TAZ via RhoA

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dc.contributor.authorBi-Oh Park-
dc.contributor.authorSeong Heon Kim-
dc.contributor.authorJong Hwan Kim-
dc.contributor.authorSeon-Young Kim-
dc.contributor.authorByoung Chul Park-
dc.contributor.authorS B Han-
dc.contributor.authorSung Goo Park-
dc.contributor.authorJeong Hoon Kim-
dc.contributor.authorS Kim-
dc.date.accessioned2021-08-03T15:30:37Z-
dc.date.available2021-08-03T15:30:37Z-
dc.date.issued2021-
dc.identifier.issn1016-8478-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24590-
dc.description.abstractGPR43 (also known as FFAR2 or FFA2) is a G-protein-coupled receptor primarily expressed in immune cells, enteroendocrine cells and adipocytes that recognizes short-chain fatty acids, such as acetate, propionate, and butyrate, likely to be implicated in innate immunity and host energy homeostasis. Activated GPR43 suppresses the cAMP level and induces Ca2+ flux via coupling to Gαi and Gαq families, respectively. Additionally, GPR43 is reported to facilitate phosphorylation of ERK through G-protein-dependent pathways and interacts with β-arrestin 2 to inhibit NF-κB signaling. However, other G-protein-dependent and independent signaling pathways involving GPR43 remain to be established. Here, we have demonstrated that GPR43 augments Rho GTPase signaling. Acetate and a synthetic agonist effectively activated RhoA and stabilized YAP/TAZ transcriptional coactivators through interactions of GPR43 with Gαq/11 and Gα12/13. Acetate-induced nuclear accumulation of YAP was blocked by a GPR43-specific inverse agonist. The target genes induced by YAP/TAZ were further regulated by GPR43. Moreover, in THP-1-derived M1-like macrophage cells, the Rho-YAP/TAZ pathway was activated by acetate and a synthetic agonist. Our collective findings suggest that GPR43 acts as a mediator of the Rho-YAP/TAZ pathway.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleThe short-chain fatty acid receptor GPR43 modulates YAP/TAZ via RhoA-
dc.title.alternativeThe short-chain fatty acid receptor GPR43 modulates YAP/TAZ via RhoA-
dc.typeArticle-
dc.citation.titleMolecules and Cells-
dc.citation.number7-
dc.citation.endPage467-
dc.citation.startPage458-
dc.citation.volume44-
dc.contributor.affiliatedAuthorBi-Oh Park-
dc.contributor.affiliatedAuthorSeong Heon Kim-
dc.contributor.affiliatedAuthorJong Hwan Kim-
dc.contributor.affiliatedAuthorSeon-Young Kim-
dc.contributor.affiliatedAuthorByoung Chul Park-
dc.contributor.affiliatedAuthorSung Goo Park-
dc.contributor.affiliatedAuthorJeong Hoon Kim-
dc.contributor.alternativeName박비오-
dc.contributor.alternativeName김성헌-
dc.contributor.alternativeName김종환-
dc.contributor.alternativeName김선영-
dc.contributor.alternativeName박병철-
dc.contributor.alternativeName한상배-
dc.contributor.alternativeName박성구-
dc.contributor.alternativeName김정훈-
dc.contributor.alternativeName김선홍-
dc.identifier.bibliographicCitationMolecules and Cells, vol. 44, no. 7, pp. 458-467-
dc.identifier.doi10.14348/molcells.2021.0021-
dc.subject.keywordGPR43-
dc.subject.keywordRhoA-
dc.subject.keywordShort-chain fatty acid-
dc.subject.keywordTAZ-
dc.subject.keywordYAP-
dc.subject.localGPR43-
dc.subject.localRHOA-
dc.subject.localRhoA-
dc.subject.localshort-chain fatty acids-
dc.subject.localShort-chain fatty acids (SCFAs)-
dc.subject.localShort-chain fatty acid-
dc.subject.localShort-chain fatty acids-
dc.subject.localTAZ-
dc.subject.localYAP-
dc.description.journalClassY-
Appears in Collections:
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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