Signaling pathways regulated by UBR box-containing E3 ligases

Cited 4 time in scopus
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Title
Signaling pathways regulated by UBR box-containing E3 ligases
Author(s)
Jung Gi Kim; Ho Chul Shin; Taewook Seo; L Nawale; Goeun Han; Bo Yeon KimSeung Jun KimHyunjoo Cha-Molstad
Bibliographic Citation
International Journal of Molecular Sciences, vol. 22, no. 15, pp. 8323-8323
Publication Year
2021
Abstract
UBR box E3 ligases, also called N-recognins, are integral components of the N-degron pathway. Representative N-recognins include UBR1, UBR2, UBR4, and UBR5, and they bind destabilizing N-terminal residues, termed N-degrons. Understanding the molecular bases of their substrate recognition and the biological impact of the clearance of their substrates on cellular signaling pathways can provide valuable insights into the regulation of these pathways. This review provides an overview of the current knowledge of the binding mechanism of UBR box N-recognin/N-degron interactions and their roles in signaling pathways linked to G-protein-coupled receptors, apoptosis, mitochondrial quality control, inflammation, and DNA damage. The targeting of these UBR box N-recognins can provide potential therapies to treat diseases such as cancer and neurodegenerative diseases.
Keyword
UBR Box E3 ligasesN-recogninArg/N-degron pathwayN-degronG-protein signalingApoptosisMitochondrial quality controlInflammatory responseDNA damage
ISSN
1661-6596
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/ijms22158323
Type
Article
Appears in Collections:
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Ochang Branch Institute > Nucleic Acid Therapeutics Research Center > 1. Journal Articles
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