DC Field | Value | Language |
---|---|---|
dc.contributor.author | R Y Utomo | - |
dc.contributor.author | Y Asawa | - |
dc.contributor.author | S Okada | - |
dc.contributor.author | Hyun Seung Ban | - |
dc.contributor.author | A Yoshimori | - |
dc.contributor.author | J Bajorath | - |
dc.contributor.author | H Nakamura | - |
dc.date.accessioned | 2021-08-17T15:30:24Z | - |
dc.date.available | 2021-08-17T15:30:24Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/24640 | - |
dc.description.abstract | Amyloid β (Aβ) aggregation inhibitor activity cliff involving a curcumin structure was predicted using the SAR Matrix method on the basis of 697 known Aβ inhibitors from ChEMBL (data set 2487). Among the compounds predicted, compound B was found to possess approximately 100 times higher inhibitory activity toward Aβ aggregation than curcumin. TEM images indicate that compound B induced the shortening of Aβ fibrils and increased the generation of Aβ oligomers in a concentration dependent manner. Furthermore, compound K, in which the methyl ester of compound B was replaced by the tert-butyl ester, possessed low cytotoxicity on N2A cells and attenuated Aβ-induced cytotoxicity, indicating that compound K would have an ability for preventing neurotoxicity caused by Aβ aggregation. | - |
dc.publisher | Elsevier | - |
dc.title | Development of curcumin-based amyloid β aggregation inhibitors for Alzheimer's disease using the SAR matrix approach | - |
dc.title.alternative | Development of curcumin-based amyloid β aggregation inhibitors for Alzheimer's disease using the SAR matrix approach | - |
dc.type | Article | - |
dc.citation.title | Bioorganic & Medicinal Chemistry | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 116357 | - |
dc.citation.startPage | 116357 | - |
dc.citation.volume | 46 | - |
dc.contributor.affiliatedAuthor | Hyun Seung Ban | - |
dc.contributor.alternativeName | Utomo | - |
dc.contributor.alternativeName | Asawa | - |
dc.contributor.alternativeName | Okada | - |
dc.contributor.alternativeName | 반현승 | - |
dc.contributor.alternativeName | Yoshimori | - |
dc.contributor.alternativeName | Bajorath | - |
dc.contributor.alternativeName | Nakamura | - |
dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry, vol. 46, pp. 116357-116357 | - |
dc.identifier.doi | 10.1016/j.bmc.2021.116357 | - |
dc.subject.keyword | SAR matrix | - |
dc.subject.keyword | Curcumin | - |
dc.subject.keyword | Amyloid β | - |
dc.subject.keyword | Alzheimer’s disease | - |
dc.subject.keyword | Neurotoxicity | - |
dc.subject.local | SAR matrix | - |
dc.subject.local | Curcumin | - |
dc.subject.local | curcumin | - |
dc.subject.local | Amyloid beta | - |
dc.subject.local | Amyloid β | - |
dc.subject.local | amyloid-β | - |
dc.subject.local | Amyloid-beta | - |
dc.subject.local | alzheimer's disease | - |
dc.subject.local | Alzheimer’s disease (AD) | - |
dc.subject.local | Alzheimer’s disease | - |
dc.subject.local | Alzheimer's Disease | - |
dc.subject.local | Alzheimer disease | - |
dc.subject.local | Alzheimer's disease (AD) | - |
dc.subject.local | Alzheimer′s disease | - |
dc.subject.local | Alzheimer's disease | - |
dc.subject.local | Neurotoxicity | - |
dc.subject.local | neurotoxicity | - |
dc.description.journalClass | Y | - |
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