Bovine serum albumin-immobilized black phosphorus-based γ-Fe2O3 nanocomposites: a promising biocompatible nanoplatform

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Title
Bovine serum albumin-immobilized black phosphorus-based γ-Fe2O3 nanocomposites: a promising biocompatible nanoplatform
Author(s)
A Naskar; S Lee; Dongjoon Ko; Semi Kim; K S Kim
Bibliographic Citation
Biomedicines, vol. 9, no. 8, pp. 858-858
Publication Year
2021
Abstract
The interactions between proteins and nanoparticles need to be fully characterized as the immobilization of proteins onto various nanoplatforms in the physiological system often results in the change of surface of the protein molecules to avoid any detrimental issues related to their biomedical applications. Hence, in this article, the successful low-temperature synthesis of a BP-based γ-Fe2O3 (IB) nanocomposite and its interactive behavior with bovine serum albumin (BSA)-a molecule with chemical similarity and high sequence identity to human serum albumin-are described. To confirm the formation of γ-Fe2O3 and the IB nanocomposite, X-ray diffraction, transmission electron microscopy, and X-ray photoelectron spectroscopy analyses of the materials were performed. Additionally, the physical interaction between BSA and the IB nanocomposite was confirmed via UV-Vis and photoluminescence spectral analyses. Finally, the biocompatibility of the BSA-immobilized IB nanocomposite was verified using an in vitro cytotoxicity assay with HCT-15 colon cancer cells. Our findings demonstrate that this newly developed nanocomposite has potential utility as a biocompatible nanoplatform for various biomedical applications.
Keyword
Black phosphorus nanocompositeNanomaterial-protein interactionSerum albumin proteinIron oxide nanocompositeNanoplatform
ISSN
2227-9059
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/biomedicines9080858
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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