Polyketides and meroterpenes from the marine-derived fungi Aspergillus unguis 158SC-067 and A. flocculosus 01NT-1.1.5 and their cytotoxic and antioxidant activities

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dc.contributor.authorG V Anh-
dc.contributor.authorJong Soon Kang-
dc.contributor.authorB K Choi-
dc.contributor.authorH S Lee-
dc.contributor.authorC S Heo-
dc.contributor.authorH J Shin-
dc.date.accessioned2021-08-24T15:30:39Z-
dc.date.available2021-08-24T15:30:39Z-
dc.date.issued2021-
dc.identifier.issn16603397-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24668-
dc.description.abstractTen secondary metabolites, including a new grifolin analog, grifolin B (1); a new homovalencic acid derivative, 12-hydroxyhomovalencic acid (7); and a compound isolated from a natural source for the first time (9), along with seven known compounds, grifolin (2), averantin (3), 7-chloroaverantin (4), 1′-O-methylaverantin (5), 7-hydroxy-2-(2-hydroxypropyl)-5-pentylchromone (6), homovalencic acid (8), and bekeleylactone E (10), were isolated from two fungal strains. The structures of 1-10 were identified by detailed analysis and comparison of their spectroscopic data with literature values. Compounds 9 and 10 showed moderate cytotoxic activity against a panel of cancer cell lines (PC-3, HCT-15, MDA-MB-231, ACHN, NCI-H23, NUGC-3), with the GI50 values ranging from 1.1 μM to 3.6 μM, whereas 1 displayed a weak 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity without cytotoxicity against all tested cell lines.-
dc.publisherMDPI-
dc.titlePolyketides and meroterpenes from the marine-derived fungi Aspergillus unguis 158SC-067 and A. flocculosus 01NT-1.1.5 and their cytotoxic and antioxidant activities-
dc.title.alternativePolyketides and meroterpenes from the marine-derived fungi Aspergillus unguis 158SC-067 and A. flocculosus 01NT-1.1.5 and their cytotoxic and antioxidant activities-
dc.typeArticle-
dc.citation.titleMarine Drugs-
dc.citation.number8-
dc.citation.endPage415-
dc.citation.startPage415-
dc.citation.volume19-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.alternativeNameAnh-
dc.contributor.alternativeName강종순-
dc.contributor.alternativeName최병규-
dc.contributor.alternativeName이화선-
dc.contributor.alternativeName허창수-
dc.contributor.alternativeName신희재-
dc.identifier.bibliographicCitationMarine Drugs, vol. 19, no. 8, pp. 415-415-
dc.identifier.doi10.3390/md19080415-
dc.subject.keywordMarine-derived fungi-
dc.subject.keywordAspergillus sp.-
dc.subject.keywordPolyketides-
dc.subject.keywordMeroterpenes-
dc.subject.keywordAntioxidant-
dc.subject.keywordCytotoxicity-
dc.subject.localMarine-derived fungi-
dc.subject.localAspergillus sp.-
dc.subject.localPolyketides-
dc.subject.localPolyketide-
dc.subject.localAntioxidant-
dc.subject.localCytotoxicity-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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