Anti-inflammatory effects of Weigela subsessilis callus extract via suppression of MAPK and NF-κB signaling

Cited 0 time in scopus
Metadata Downloads
Title
Anti-inflammatory effects of Weigela subsessilis callus extract via suppression of MAPK and NF-κB signaling
Author(s)
H J Lim; Eun Yee Jie; I S Park; S J Kim; Woo-Seok Ahn; S I Jeong; Suk Weon Kim; C H Jung
Bibliographic Citation
Plants-Basel, vol. 10, no. 8, pp. 1635-1635
Publication Year
2021
Abstract
Weigela subsessilis is used in folk medicine to treat pain and allergic syndromes in Korea. However, the antibacterial and anti-inflammatory activities of W. subsessilis callus extract remain unexplored. In this study, we aimed to evaluate the W. subsessilis callus of pharmacological activity. Therefore, we first established in vitro calluses of W.subsessilis via plant tissue culture methods. We then evaluated the antioxidant and anti-inflammatory effects of W. subsessilis callus extract in lipopolysaccharide (LPS)-treated RAW264.7 macrophage cells. The W. subsessilis callus extract showed antioxidant and anti-inflammatory effects. These effects were regulated via suppression of mitogen-activated protein kinase signaling through LPS-induced translocation of nuclear factor kappa B (NF-κB) p65 from the cytoplasm to the nucleus. W. subsessilis callus extract also showed antibacterial and anti-inflammatory activities in Propionibacterium acnes-treated HaCaT keratinocyte cells. These results indicate that W. subsessilis callus extract has antioxidant, antibacterial and anti-inflammatory activities, suggesting its possible application in the treatment of inflammatory disorders.
Keyword
Weigela subsessilisCallusAntioxidantAntibacterial activityAnti-inflammatoryInflammatory disorder
ISSN
2223-7747
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/plants10081635
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.