Human blood vessel organoids penetrate human cerebral organoids and form a vessel-like system

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dc.contributor.authorYujin Ahn-
dc.contributor.authorJu-hyun An-
dc.contributor.authorHae Jun Yang-
dc.contributor.authorDong Gil Lee-
dc.contributor.authorJieun Kim-
dc.contributor.authorHyebin Koh-
dc.contributor.authorYoung-Ho Park-
dc.contributor.authorBong-Seok Song-
dc.contributor.authorBo Woong Sim-
dc.contributor.authorH J Lee-
dc.contributor.authorJong-Hee Lee-
dc.contributor.authorSun-Uk Kim-
dc.date.accessioned2021-08-30T15:30:27Z-
dc.date.available2021-08-30T15:30:27Z-
dc.date.issued2021-
dc.identifier.issn20734409-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24681-
dc.description.abstractVascularization of tissues, organoids and organ-on-chip models has been attempted using endothelial cells. However, the cultured endothelial cells lack the capacity to interact with other somatic cell types, which is distinct from developing vascular cells in vivo. Recently, it was demonstrated that blood vessel organoids (BVOs) recreate the structure and functions of developing human blood vessels. However, the tissue-specific adaptability of BVOs had not been assessed in somatic tissues. Herein, we investigated whether BVOs infiltrate human cerebral organoids and form a blood-brain barrier. As a result, vascular cells arising from BVOs penetrated the cerebral organoids and developed a vessel-like architecture composed of CD31+ endothelial tubes coated with SMA+ or PDGFR+ mural cells. Molecular markers of the blood-brain barrier were detected in the vascularized cerebral organoids. We revealed that BVOs can form neural-specific blood-vessel networks that can be maintained for over 50 days.-
dc.publisherMDPI-
dc.titleHuman blood vessel organoids penetrate human cerebral organoids and form a vessel-like system-
dc.title.alternativeHuman blood vessel organoids penetrate human cerebral organoids and form a vessel-like system-
dc.typeArticle-
dc.citation.titleCells-
dc.citation.number8-
dc.citation.endPage2036-
dc.citation.startPage2036-
dc.citation.volume10-
dc.contributor.affiliatedAuthorYujin Ahn-
dc.contributor.affiliatedAuthorJu-hyun An-
dc.contributor.affiliatedAuthorHae Jun Yang-
dc.contributor.affiliatedAuthorDong Gil Lee-
dc.contributor.affiliatedAuthorJieun Kim-
dc.contributor.affiliatedAuthorHyebin Koh-
dc.contributor.affiliatedAuthorYoung-Ho Park-
dc.contributor.affiliatedAuthorBong-Seok Song-
dc.contributor.affiliatedAuthorBo Woong Sim-
dc.contributor.affiliatedAuthorJong-Hee Lee-
dc.contributor.affiliatedAuthorSun-Uk Kim-
dc.contributor.alternativeName안유진-
dc.contributor.alternativeName안주현-
dc.contributor.alternativeName양해준-
dc.contributor.alternativeName이동길-
dc.contributor.alternativeName김지은-
dc.contributor.alternativeName고혜빈-
dc.contributor.alternativeName박영호-
dc.contributor.alternativeName송봉석-
dc.contributor.alternativeName심보웅-
dc.contributor.alternativeName이홍-
dc.contributor.alternativeName이종희-
dc.contributor.alternativeName김선욱-
dc.identifier.bibliographicCitationCells, vol. 10, no. 8, pp. 2036-2036-
dc.identifier.doi10.3390/cells10082036-
dc.subject.keywordVascularization-
dc.subject.keywordBlood vessel organoid-
dc.subject.keywordCerebral organoid-
dc.subject.keywordBlood-brain barrier-
dc.subject.keywordVessel structure-
dc.subject.keywordOrganoids-
dc.subject.keywordBlood vessel formation-
dc.subject.keywordBrain organoid-
dc.subject.localCerebral organoid-
dc.subject.localBlood-brain barrier-
dc.subject.localOrganoids-
dc.subject.localorganoid-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
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