Anti-mullerian hormone negatively regulates osteoclast differentiation by suppressing the receptor activator of nuclear factor-κB ligand pathway

Cited 1 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorJ H Kim-
dc.contributor.authorYong Ryoul Yang-
dc.contributor.authorKi-Sun Kwon-
dc.contributor.authorN Kim-
dc.date.accessioned2021-09-16T15:30:13Z-
dc.date.available2021-09-16T15:30:13Z-
dc.date.issued2021-
dc.identifier.issn22876375-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24739-
dc.description.abstractBackground: Multiple members of the transforming growth factor-β (TGF-β) superfamily have well-established roles in bone homeostasis. Anti-Mullerian hormone (AMH) is a member of TGF-β superfamily of glycoproteins that is responsible for the regression of fetal Mullerian ducts and the transcription inhibition of gonadal steroidogenic enzymes. However, the involvement of AMH in bone remodeling is unknown. Therefore, we investigated whether AMH has an effect on bone cells as other TGF-β superfamily members do. Methods: To identify the roles of AMH in bone cells, we administered AMH during osteoblast and osteoclast differentiation, cultured the cells, and then stained the cultured cells with Alizarin red and tartrate-resistant acid phosphatase, respectively. We analyzed the expression of osteoblast- or osteoclast-related genes using real-time polymerase chain reaction and western blot. Results: AMH does not affect bone morphogenetic protein 2-mediated osteoblast differentiation but inhibits receptor activator of nuclear factor-κB (NF-κB) ligand-induced osteoclast differentiation. The inhibitory effect of AMH on osteoclast differentiation is mediated by IκB-NF-κB signaling. Conclusions: AMH negatively regulates osteoclast differentiation without affecting osteoblast differentiation.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleAnti-mullerian hormone negatively regulates osteoclast differentiation by suppressing the receptor activator of nuclear factor-κB ligand pathway-
dc.title.alternativeAnti-mullerian hormone negatively regulates osteoclast differentiation by suppressing the receptor activator of nuclear factor-κB ligand pathway-
dc.typeArticle-
dc.citation.titleJournal of Bone Metabolism-
dc.citation.number3-
dc.citation.endPage230-
dc.citation.startPage223-
dc.citation.volume28-
dc.contributor.affiliatedAuthorYong Ryoul Yang-
dc.contributor.affiliatedAuthorKi-Sun Kwon-
dc.contributor.alternativeName김정하-
dc.contributor.alternativeName양용렬-
dc.contributor.alternativeName권기선-
dc.contributor.alternativeName김낙성-
dc.identifier.bibliographicCitationJournal of Bone Metabolism, vol. 28, no. 3, pp. 223-230-
dc.identifier.doi10.11005/jbm.2021.28.3.223-
dc.subject.keywordAnti-mullerian hormone-
dc.subject.keywordOsteoblasts-
dc.subject.keywordOsteoclasts-
dc.subject.keywordTGF-beta superfamily proteins-
dc.subject.localOsteoblasts-
dc.subject.localOsteoblast-
dc.subject.localOsteoclasts-
dc.subject.localOsteoclast-
dc.description.journalClassN-
Appears in Collections:
Division of Research on National Challenges > Aging Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.