Four-week repeated intravenous dose toxicity of self-assembled-micelle inhibitory RNA-targeting amphiregulin in mice

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dc.contributor.authorH Y Kim-
dc.contributor.authorT R Kim-
dc.contributor.authorS H Kim-
dc.contributor.authorI H Kim-
dc.contributor.authorJ O Lim-
dc.contributor.authorJ H Park-
dc.contributor.authorS Yun-
dc.contributor.authorIn Chul Lee-
dc.contributor.authorH O Park-
dc.contributor.authorJ C Kim-
dc.date.accessioned2021-09-17T15:30:24Z-
dc.date.available2021-09-17T15:30:24Z-
dc.date.issued2021-
dc.identifier.issn1091-5818-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24743-
dc.description.abstractThe present study investigated the potential subchronic toxicity of self-assembled-micelle inhibitory RNA-targeting amphiregulin (SAMiRNA-AREG) in mice. The test reagent was administered once-daily by intravenous injection for 4 weeks at 0, 100, 200, or 300 mg/kg/day doses. Additional recovery groups (vehicle control and high dose groups) were observed for a 2-week recovery period. During the test period, mortality, clinical signs, body weight, food consumption, ophthalmology, urinalysis, hematology, serum biochemistry, gross pathology, organ weight, and histopathology were examined. An increase in the percentages of basophil and large unstained cells was observed in the 200 and 300 mg/kg/day groups of both sexes. In addition, the absolute and relative weights of the spleen were higher in males given 300 mg/kg/day relative to the concurrent controls. However, these findings were considered of no toxicological significance because the changes were minimal, were not accompanied by other relevant results (eg, correlating microscopic changes), and were not observed at the end of the 2-week recovery period indicating recovery of the findings. Based on the results, SAMiRNA-AREG did not cause treatment-related adverse effects at dose levels of up to 300 mg/kg/day in mice after 4-week repeated intravenous doses. Under these conditions, the no-observed-adverse-effect level of the SAMiRNA-AREG was ≥300 mg/kg/day in both sexes and no target organs were identified.-
dc.publisherSage-
dc.titleFour-week repeated intravenous dose toxicity of self-assembled-micelle inhibitory RNA-targeting amphiregulin in mice-
dc.title.alternativeFour-week repeated intravenous dose toxicity of self-assembled-micelle inhibitory RNA-targeting amphiregulin in mice-
dc.typeArticle-
dc.citation.titleInternational Journal of Toxicology-
dc.citation.number5-
dc.citation.endPage465-
dc.citation.startPage453-
dc.citation.volume40-
dc.contributor.affiliatedAuthorIn Chul Lee-
dc.contributor.alternativeName김현영-
dc.contributor.alternativeName김태림-
dc.contributor.alternativeName김성환-
dc.contributor.alternativeName김인현-
dc.contributor.alternativeName임제오-
dc.contributor.alternativeName박준홍-
dc.contributor.alternativeName윤선길-
dc.contributor.alternativeName이인철-
dc.contributor.alternativeName박한오-
dc.contributor.alternativeName김종춘-
dc.identifier.bibliographicCitationInternational Journal of Toxicology, vol. 40, no. 5, pp. 453-465-
dc.identifier.doi10.1177/10915818211031241-
dc.subject.keywordSelf-assembled-micelle inhibitory RNA nanoparticle-
dc.subject.keywordAmphiregulin-
dc.subject.keywordRepeated dose toxicity-
dc.subject.keywordNo-observed-adverse-effect level-
dc.subject.keywordTarget organ-
dc.subject.localSelf-assembled-micelle inhibitory RNA nanoparticle-
dc.subject.localAmphiregulin-
dc.subject.localrepeated dose toxicity-
dc.subject.localRepeated dose toxicity-
dc.subject.localNo-observed-adverse-effect level-
dc.subject.localTarget organ-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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