A role of stress sensor Nrf2 in stimulating thermogenesis and energy expenditure

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Title
A role of stress sensor Nrf2 in stimulating thermogenesis and energy expenditure
Author(s)
S H Chang; Jeong Soo Lee; U J Yun; K W Park
Bibliographic Citation
Biomedicines, vol. 9, no. 9, pp. 1196-1196
Publication Year
2021
Abstract
During chronic cold stress, thermogenic adipocytes generate heat through uncoupling of mitochondrial respiration from ATP synthesis. Recent discovery of various dietary phytochemicals, endogenous metabolites, synthetic compounds, and their molecular targets for stimulating thermo-genesis has provided promising strategies to treat or prevent obesity and its associated metabolic diseases. Nuclear factor E2 p45-related factor 2 (Nrf2) is a stress response protein that plays an important role in obesity and metabolisms. However, both Nrf2 activation and Nrf2 inhibition can suppress obesity and metabolic diseases. Here, we summarized and discussed conflicting findings of Nrf2 activities accounting for part of the variance in thermogenesis and energy metabolism. We also discussed the utility of Nrf2-activating mechanisms for their potential applications in stimulating energy expenditure to prevent obesity and improve metabolic deficits.
Keyword
Nrf2UncouplingThermogenesisEnergy expenditureObesityMetabolic diseases
ISSN
2227-9059
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/biomedicines9091196
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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