Evaluation of cellular response and drug delivery efficacy of nanoporous stainless steel material

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Title
Evaluation of cellular response and drug delivery efficacy of nanoporous stainless steel material
Author(s)
I Bae; Kyung Seob Lim; J K Park; J H Song; S H Oh; J W Kim; Z Zhang; C Park; J T Koh
Bibliographic Citation
Biomaterials Research, vol. 25, pp. 30-30
Publication Year
2021
Abstract
Objective: Various surface modification techniques that can further improve the function and usability of stainless steel as a medical device have been reported. In the present study, the physical and biological properties of nanoporous stainless steel as well as its usefulness for drug delivery were assessed. Methods: The specimen was prepared with a circular disk shape (15 mm in diameter and 1 mm in thickness). The disk was subjected to electropolishing at a constant voltage of 20 V and 10 A for 10 min in an acidic environment (50% H2SO4). Everolimus (EVL) was used as a testing drug for drug-loading capacity of the material surface and release kinetics. The physiobiological properties of the material were assessed using platelet adhesion, and smooth muscle cell (SMC) adhesion, migration, and proliferation assays. Results: The surface roughness of the postpolishing group was greater than that of the nonpolishing group. Platelet adhesion and SMC adhesion and migration were inhibited in the postpolishing group compared to those in the prepolishing group. In the postpolishing group, the total amount of EVL on the surface (i.e., drug storage rate) was higher and the drug release rate was lower, with half the amount of the EVL released within 4 days compared with only 1 day for that of the prepolishing group. Conclusion: Taken together, this stainless steel with a nanoporous surface could be used as a medical device for controlling cellular responses and carrying drugs.
Keyword
Nanoporous structureStainless steelSurface modificationCellular responseDrug delivery
ISSN
1226-1226
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1186/s40824-021-00232-8
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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