Biomimetic nanopillar-based biosensor for label-free detection of influenza A virus

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Title
Biomimetic nanopillar-based biosensor for label-free detection of influenza A virus
Author(s)
Wang Sik Lee; J Ahn; S Jung; J LeeTaejoon KangJinyoung Jeong
Bibliographic Citation
Biochip Journal, vol. 15, pp. 260-267
Publication Year
2021
Abstract
Since the first emergence of influenza viruses, they have caused the flu seasonally worldwide. Precise detection of influenza viruses is required to prevent the spreading of the disease. Herein, we developed an optical biosensor using peptide-immobilized nanopillar structures for the label-free detection of influenza viruses. The spin-on-glass nanopillar structures were fabricated by nanoimprint lithography. A sialic acid-mimic peptide, which can specifically bind to hemagglutinin on the surface of the influenza virus, was immobilized onto the nanopillars via polymerized dopamine. The constructed nanopillar sensor enabled us to detect influenza A viruses in the range of 10 3-10-5 plaque-forming units through simple measurements of reflectance. Our findings suggest that biomimetic modification of nanopillar structures can be an alternative method for the immunodiagnosis of influenza viruses.
Keyword
NanopillarInfuenza virusPeptidePolydopamineRefectance
ISSN
1976-0280
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.1007/s13206-021-00027-y
Type
Article
Appears in Collections:
Division of Biomaterials Research > Bionanotechnology Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
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