The biocatalytic production of 3-hydroxypropionaldehyde and evaluation of its stability

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dc.contributor.authorJung-Hyun Ju-
dc.contributor.authorSang Gyu Jeon-
dc.contributor.authorK M Lee-
dc.contributor.authorSun-Yeon Heo-
dc.contributor.authorMinsoo Kim-
dc.contributor.authorChul Ho Kim-
dc.contributor.authorBaek Rock Oh-
dc.date.accessioned2021-10-05T15:30:46Z-
dc.date.available2021-10-05T15:30:46Z-
dc.date.issued2021-
dc.identifier.issn20734344-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24824-
dc.description.abstract3-Hydroxypropionaldehyde (3-HPA, reuterin) is a broad-spectrum natural antimicrobial agent used in the food industry and other fields. The low yield from the industrial production of 3-HPA using Lactobacillus reuteri and the spontaneous conversion of 3-HPA to acrolein have limited its more widespread use. We isolated L. reuteri BR201 as a biocatalyst for 3-HPA production and confirmed the effect of each factor in the two-step procedure for 3-HPA bioconversion. After initial cultivation for 8 h (late exponential phase), this isolate produced 378 mM of 3-HPA in 1 h at a concentration of OD600 nm 100, 30 °C, and an initial glycerol concentration of 500 mM. This is the highest reported biocatalytic yield of 3-HPA from a glycerol aqueous solution without additives. We confirmed that 4 mM of 3-HPA had antimicrobial activity against five pathogens. The degradation of 3-HPA to acrolein was greater at high temperatures, and there was little degradation when 3-HPA was maintained at 4 °C for 4 weeks. Our results may be useful for future applications of 3-HPA.-
dc.publisherMDPI-
dc.titleThe biocatalytic production of 3-hydroxypropionaldehyde and evaluation of its stability-
dc.title.alternativeThe biocatalytic production of 3-hydroxypropionaldehyde and evaluation of its stability-
dc.typeArticle-
dc.citation.titleCatalysts-
dc.citation.number10-
dc.citation.endPage1139-
dc.citation.startPage1139-
dc.citation.volume11-
dc.contributor.affiliatedAuthorJung-Hyun Ju-
dc.contributor.affiliatedAuthorSang Gyu Jeon-
dc.contributor.affiliatedAuthorSun-Yeon Heo-
dc.contributor.affiliatedAuthorMinsoo Kim-
dc.contributor.affiliatedAuthorChul Ho Kim-
dc.contributor.affiliatedAuthorBaek Rock Oh-
dc.contributor.alternativeName주정현-
dc.contributor.alternativeName전상규-
dc.contributor.alternativeName이경민-
dc.contributor.alternativeName허선연-
dc.contributor.alternativeName김민수-
dc.contributor.alternativeName김철호-
dc.contributor.alternativeName오백록-
dc.identifier.bibliographicCitationCatalysts, vol. 11, no. 10, pp. 1139-1139-
dc.identifier.doi10.3390/catal11101139-
dc.subject.keywordLactobacillus reuteri-
dc.subject.keyword3-hydroxypropionaldehyde-
dc.subject.keywordReuterin-
dc.subject.keywordAntibiotic-
dc.subject.keywordStability evaluation-
dc.subject.localLactobacillus reuteri-
dc.subject.localAntibiotic-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
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