Sudden cardiac death as a naturally-occurring ventricular hypertrophy in Macaca fascicularis

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Title
Sudden cardiac death as a naturally-occurring ventricular hypertrophy in Macaca fascicularis
Author(s)
Hyeongu Yeo; Junghyung Park; H K Kim; J M Lee; Bon-Sang KooJeonghee AnChang-Yeop JeonYou Jung AnWon Seok ChoiSung Hyun Park; Jincheol Seo; Jinyoung Won; Keon Woo Kim; Jiyeon Cho; Yu Gyeong Kim; Min Ji Kim; Jung Bae Seong; Jae Won Huh; S S Kim; Youngjeon LeeKyung Seob Lim
Bibliographic Citation
Journal of Biomedical and Translational Research, vol. 22, no. 3, pp. 135-139
Publication Year
2021
Abstract
Naturally occurring left ventricular hyperplasia is a rare but lethal disease. There are very few reports of this cardiac disease in captive nonhuman primates. In a colony of Macaca mulatta (Rhesus monkey) at California National Primate Research Center, a large number of rhesus macaques were diagnosed by autopsy with naturally occurring left ventricular hypertrophy without obvious underlying diseases over a 22-year period. The confirmatory diagnosis of ventricular hypertrophy was based on findings of notable left ventricular concentric hypertrophy with reduced left ventricular lumen, which is very similar to human ventricular hypertrophy cases. This report discusses an 11-year-old Macaca fascicularis monkey (Cynomolgus monkey, crab-eating macaque), weighing 2.95 kg, that was presented for enrollment in a pharmacokinetic (PK) study. During the PK experiment, the monkey died following a sudden decrease in percutaneous oxygen saturation and heart rate. Gross and histological examinations of the heart were performed. On gross pathology, the left ventricular wall was thickened, and the chamber lumen was reduced. In histopathological examination using hematoxylineosin and Masson-trichrome stains, fibrosis and myocyte disarray were not observed, but an increased cell density, compared to the normal heart, was confirmed. The autopsy results confirmed left ventricular hyperplasia as the major cause of death.
Keyword
Non-human primateAutopsyHypertrophy, left ventricularSudden cardiac deathPathology
ISSN
2508-1357
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.12729/jbtr.2021.22.3.135
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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