ERO1-PDI redox signaling in health and disease

Cited 2 time in scopus
Metadata Downloads
Title
ERO1-PDI redox signaling in health and disease
Author(s)
V Jha; T Kumari; V Manickam; Z Assar; K L Olson; Jeong Ki Min; J Cho
Bibliographic Citation
Antioxidants & Redox Signaling, vol. 35, no. 13, pp. 1093-1115
Publication Year
2021
Abstract
Significance: Protein disulfide isomerase (PDI) and endoplasmic reticulum oxidoreductase 1 (ERO1) are crucial for oxidative protein folding in the endoplasmic reticulum (ER). These enzymes are frequently overexpressed and secreted, and they contribute to the pathology of neurodegenerative, cardiovascular, and metabolic diseases. Recent Advances: Tissue-specific knockout mouse models and pharmacologic inhibitors have been developed to advance our understanding of the cell-specific functions of PDI and ERO1. In addition to their roles in protecting cells from the unfolded protein response and oxidative stress, recent studies have revealed that PDI and ERO1 also function outside of the cells. Critical Issues: Despite the well-known contributions of PDI and ERO1 to specific disease pathology, the detailed molecular and cellular mechanisms underlying these activities remain to be elucidated. Further, although PDI and ERO1 inhibitors have been identified, the results from previous studies require careful evaluation, as many of these agents are not selective and may have significant cytotoxicity. Future Directions: The functions of PDI and ERO1 in the ER have been extensively studied. Additional studies will be required to define their functions outside the ER.
Keyword
PDIERO1Oxidative ER stressUnfolded protein responseDiseaseInhibitors
ISSN
1523-0864
Publisher
Mary Ann Liebert, Inc
DOI
http://dx.doi.org/10.1089/ars.2021.0018
Type
Article
Appears in Collections:
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.