ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota

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dc.contributor.authorS Kim-
dc.contributor.authorJ Y Lee-
dc.contributor.authorS G Shin-
dc.contributor.authorJ K Kim-
dc.contributor.authorP Silwal-
dc.contributor.authorY J Kim-
dc.contributor.authorNa-Ri Shin-
dc.contributor.authorP S Kim-
dc.contributor.authorMinho Won-
dc.contributor.authorS H Lee-
dc.contributor.authorS Y Kim-
dc.contributor.authorM Sasai-
dc.contributor.authorM Yamamoto-
dc.contributor.authorJ M Kim-
dc.contributor.authorJ W Bae-
dc.contributor.authorE K Jo-
dc.date.accessioned2021-10-18T15:30:24Z-
dc.date.available2021-10-18T15:30:24Z-
dc.date.issued2021-
dc.identifier.issn1554-8627-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24901-
dc.description.abstractThe orphan nuclear receptor ESRRA (estrogen related receptor alpha) is critical in mitochondrial biogenesis and macroautophagy/autophagy function; however, the roles of ESRRA in intestinal function remain uncharacterized. Herein we identified that ESRRA acts as a key regulator of intestinal homeostasis by amelioration of colonic inflammation through activation of autophagic flux and control of host gut microbiota. Esrra-deficient mice presented with increased susceptibility to dextran sodium sulfate (DSS)-induced colitis with upregulation of intestinal inflammation. In addition, esrra-null mice had depressed AMP-activated protein kinase phosphorylation (AMPK), lower levels of TFEB (transcription factor EB), and accumulation of SQSTM1/p62 (sequestosome 1) with defective mitochondria in intestinal tissues. Esrra-deficient mice showed distinct gut microbiota composition and significantly higher microbial diversity than wild-type (WT) mice. Cohousing or fecal microbiota transplantation from WT mice to Esrra-deficient mice ameliorated DSS-induced colitis severity. Importantly, patients with ulcerative colitis (UC) had significantly decreased ESRRA expression in intestinal mucosal tissues that correlated with disease activity, suggesting clinical relevance of ESRRA in UC. Taken together, our results show that ESRRA contributes to intestinal homeostasis through autophagy activation and gut microbiota control to protect the host from detrimental inflammation and dysfunctional mitochondria.-
dc.publisherT&F (Taylor & Francis)-
dc.titleESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota-
dc.title.alternativeESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota-
dc.typeArticle-
dc.citation.titleAutophagy-
dc.citation.number10-
dc.citation.endPage2875-
dc.citation.startPage2856-
dc.citation.volume17-
dc.contributor.affiliatedAuthorNa-Ri Shin-
dc.contributor.affiliatedAuthorMinho Won-
dc.contributor.alternativeName김섭-
dc.contributor.alternativeName이준영-
dc.contributor.alternativeName신슬기-
dc.contributor.alternativeName김진경-
dc.contributor.alternativeNameSilwal-
dc.contributor.alternativeName김영재-
dc.contributor.alternativeName신나리-
dc.contributor.alternativeName김필수-
dc.contributor.alternativeName원민호-
dc.contributor.alternativeName이상희-
dc.contributor.alternativeName김수연-
dc.contributor.alternativeNameSasai-
dc.contributor.alternativeNameYamamoto-
dc.contributor.alternativeName김진만-
dc.contributor.alternativeName배진우-
dc.contributor.alternativeName조은경-
dc.identifier.bibliographicCitationAutophagy, vol. 17, no. 10, pp. 2856-2875-
dc.identifier.doi10.1080/15548627.2020.1847460-
dc.subject.keywordAutophagy-
dc.subject.keywordColitis-
dc.subject.keywordEsrra-
dc.subject.keywordGut-
dc.subject.keywordInflammation-
dc.subject.keywordInflammatory bowel diseases-
dc.subject.keywordMicrobiome-
dc.subject.keywordTranscription factor EB-
dc.subject.keywordUlcerative colitis-
dc.subject.localautophagy-
dc.subject.localAutophagy-
dc.subject.localcolitis-
dc.subject.localColitis-
dc.subject.localEsrra-
dc.subject.localGut-
dc.subject.localinflammation-
dc.subject.localInflammation-
dc.subject.localInflammatory bowel disease-
dc.subject.localInflammatory bowel diseases-
dc.subject.localInflammatory bowel disease (IBD)-
dc.subject.localInflammatory Bowel Diseases-
dc.subject.localInflammatory Bowel Disease-
dc.subject.localinflammatory bowel disease-
dc.subject.localmicrobiome-
dc.subject.localMicrobiome-
dc.subject.localTranscription factor EB-
dc.subject.localulcerative colitis-
dc.subject.localUlcerative colitis-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
Division of Bio Technology Innovation > BioProcess Engineering Center > 1. Journal Articles
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