Liposoluble portion of the red alga Pyropia yezoensis protects alcohol induced liver injury in mice

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Title
Liposoluble portion of the red alga Pyropia yezoensis protects alcohol induced liver injury in mice
Author(s)
J H Lee; G Ahn; J Y Ko; N Kang; Kyungsook Jung; E J Han; G H Kim; H J Kim; C S Choi; Y J Jeon
Bibliographic Citation
Algae, vol. 36, no. 3, pp. 219-229
Publication Year
2021
Abstract
The hepatoprotective effect of liposoluble portion of Pyropia yezoensis (PYLP) was investigated against alcohol-in-duced liver injury in mice. Fatty acids were predominant in PYLP obtained from hexane fraction of 70% EtOH extract after ultrasonication. In particular, polyunsaturated fatty acids such as eicosapentaenoic acid and linoleic acid account-ed for 56.91% of the total lipids. PYLP significantly reduced liver damage induced by the alcohol treatment in mice. PYLP treatment increased the activity of antioxidant enzymes including superoxide dismutase, catalase, and glutathion peroxidase by reducing thiobarbituric acid reactive substances. Histological observations showed that PYLP minimizes damage to living tissue induced by alcohol treatment by modulating the expression level of proteins involved in the anti-apoptotic signaling pathway. Our results suggest that PYLP, rich in polyunsaturated fatty acids extracted from the red alga P. yezoensis, will be useful as a potential liver protectant in the hangover industry.
Keyword
Alcohol damageHepatic protective effectLiposoluble portionMarine red algaPolyunsaturated fatty acidsPyropia yezoensis
ISSN
1226-2617
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.4490/algae.2021.36.4.28
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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