The role of microglia in the development of neurodegenerative diseases = 신경퇴행성 질환의 발병에서 미세아교세포의 역할

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Title
The role of microglia in the development of neurodegenerative diseases = 신경퇴행성 질환의 발병에서 미세아교세포의 역할
Author(s)
Jae-Won Lee; W Chun; H J Lee; Seong-Man Kim; Jae-Hong Min; Doo-Young KimMun-Ock KimHyung Won RyuSu Ui Lee
Bibliographic Citation
Biomedicines, vol. 9, no. 10, pp. 1449-1449
Publication Year
2021
Abstract
Microglia play an important role in the maintenance and neuroprotection of the central nervous system (CNS) by removing pathogens, damaged neurons, and plaques. Recent observations emphasize that the promotion and development of neurodegenerative diseases (NDs) are closely related to microglial activation. In this review, we summarize the contribution of microglial activation and its associated mechanisms in NDs, such as epilepsy, Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), based on recent observations. This review also briefly introduces experimental animal models of epilepsy, AD, PD, and HD. Thus, this review provides a better understanding of microglial functions in the development of NDs, suggesting that microglial targeting could be an effective therapeutic strategy for these diseases.
Keyword
Microglial activationInflammatory moleculesNeuronal damageNeurodegenerative diseases
ISSN
2227-9059
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/biomedicines9101449
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
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