Emerging approaches for solid tumor treatment using CAR-T cell therapy

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Title
Emerging approaches for solid tumor treatment using CAR-T cell therapy
Author(s)
Hyunmin Chung; Haiyoung JungJi Yoon Noh
Bibliographic Citation
International Journal of Molecular Sciences, vol. 22, no. 22, pp. 12126-12126
Publication Year
2021
Abstract
Cancer immunotherapy is becoming more important in the clinical setting, especially for cancers resistant to conventional chemotherapy, including targeted therapy. Chimeric antigen receptor (CAR)-T cell therapy, which uses patient’s autologous T cells, combined with engineered T cell receptors, has shown remarkable results, with five US Food and Drug Administration (FDA) approvals to date. CAR-T cells have been very effective in hematologic malignancies, such as diffuse large B cell lymphoma (DLBCL), B cell acute lymphoblastic leukemia (B-ALL), and multiple myeloma (MM); however, its effectiveness in treating solid tumors has not been evaluated clearly. Therefore, many studies and clinical investigations are emerging to improve the CAR-T cell efficacy in solid tumors. The novel therapeutic approaches include modifying CARs in multiple ways or developing a combination therapy with immune checkpoint inhibitors and chemotherapies. In this review, we focus on the challenges and recent advancements in CAR-T cell therapy for solid tumors.
Keyword
CAR-T cellSolid tumorChallengeCombination therapy
ISSN
1661-6596
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/ijms222212126
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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