Directly reprogrammed natural killer cells for cancer immunotherapy

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Title
Directly reprogrammed natural killer cells for cancer immunotherapy
Author(s)
Han-Seop Kim; Jae Yun Kim; Binna Seol; Cho-Lok Song; Ji Eun Jeong; Yee Sook Cho
Bibliographic Citation
Nature Biomedical Engineering, vol. 5, no. 11, pp. 1360-1376
Publication Year
2021
Abstract
Efficacious and accessible sources of natural killer (NK) cells would widen their use as immunotherapeutics, particularly for solid cancers. Here, we show that human somatic cells can be directly reprogrammed into NK cells with a CD56brightCD16bright phenotype using pluripotency transcription factors and an optimized reprogramming medium. The directly reprogrammed NK cells have strong innate-adaptive immunomodulatory activity and are highly potent against a wide range of cancer cells, including difficult-to-treat solid cancers and cancer stem cells. Both directly reprogrammed NK cells bearing a cancer-specific chimeric antigen receptor and reprogrammed NK cells in combination with antibodies competent for antibody-dependent cell-mediated cytotoxicity led to selective anticancer effects with augmented potency. The direct reprogramming of human somatic cells into NK cells is amenable to the production of autologous and allogeneic NK cells, and will facilitate the design and testing of cancer immunotherapies and combination therapies.
ISSN
2157-846X
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/s41551-021-00768-z
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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