DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jong Hyeon Yoon | - |
dc.contributor.author | Seung-Min Lee | - |
dc.contributor.author | Y Lee | - |
dc.contributor.author | Min Ju Kim | - |
dc.contributor.author | Jae Won Yang | - |
dc.contributor.author | Jeong Yi Choi | - |
dc.contributor.author | Ju Yeon Kwak | - |
dc.contributor.author | Kwang-Pyo Lee | - |
dc.contributor.author | Yong Ryoul Yang | - |
dc.contributor.author | Ki-Sun Kwon | - |
dc.date.accessioned | 2021-11-30T15:31:03Z | - |
dc.date.available | 2021-11-30T15:31:03Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/25067 | - |
dc.description.abstract | Sarcopenia is the age-related loss of muscle mass and function and no pharmacological medication has been approved for its treatment. We established an atrogin-1/MAFbx promoter assay to find drug candidates that inhibit myotube atrophy. Alverine citrate (AC) was identified using high-throughput screening of an existing drug library. AC is an established medicine for stomach and intestinal spasms. AC treatment increased myotube diameter and inhibited atrophy signals induced by either C26-conditioned medium or dexamethasone in cultured C2C12 myoblasts. AC also enhanced myoblast fusion through the upregulation of fusion-related genes during C2C12 myoblast differentiation. Oral administration of AC improves muscle mass and physical performance in aged mice, as well as hindlimb-disused mice. Taken together, our data suggest that AC may be a novel therapeutic candidate for improving muscle weakness, including sarcopenia. | - |
dc.publisher | Elsevier | - |
dc.title | Alverine citrate promotes myogenic differentiation and ameliorates muscle atrophy | - |
dc.title.alternative | Alverine citrate promotes myogenic differentiation and ameliorates muscle atrophy | - |
dc.type | Article | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 162 | - |
dc.citation.startPage | 157 | - |
dc.citation.volume | 586 | - |
dc.contributor.affiliatedAuthor | Jong Hyeon Yoon | - |
dc.contributor.affiliatedAuthor | Seung-Min Lee | - |
dc.contributor.affiliatedAuthor | Min Ju Kim | - |
dc.contributor.affiliatedAuthor | Jae Won Yang | - |
dc.contributor.affiliatedAuthor | Jeong Yi Choi | - |
dc.contributor.affiliatedAuthor | Ju Yeon Kwak | - |
dc.contributor.affiliatedAuthor | Kwang-Pyo Lee | - |
dc.contributor.affiliatedAuthor | Yong Ryoul Yang | - |
dc.contributor.affiliatedAuthor | Ki-Sun Kwon | - |
dc.contributor.alternativeName | 윤종현 | - |
dc.contributor.alternativeName | 이승민 | - |
dc.contributor.alternativeName | 이영랑 | - |
dc.contributor.alternativeName | 김민주 | - |
dc.contributor.alternativeName | 양재원 | - |
dc.contributor.alternativeName | 최정이 | - |
dc.contributor.alternativeName | 곽주연 | - |
dc.contributor.alternativeName | 이광표 | - |
dc.contributor.alternativeName | 양용렬 | - |
dc.contributor.alternativeName | 권기선 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, vol. 586, pp. 157-162 | - |
dc.identifier.doi | 10.1016/j.bbrc.2021.11.076 | - |
dc.subject.keyword | Alverine citrate | - |
dc.subject.keyword | Sarcopenia | - |
dc.subject.keyword | Skeletal muscle atrophy | - |
dc.subject.keyword | Aging | - |
dc.subject.local | Alverine citrate | - |
dc.subject.local | Sarcopenia | - |
dc.subject.local | sarcopenia | - |
dc.subject.local | Skeletal muscle atrophy | - |
dc.subject.local | Aging | - |
dc.subject.local | aging | - |
dc.description.journalClass | Y | - |
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