Alverine citrate promotes myogenic differentiation and ameliorates muscle atrophy

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dc.contributor.authorJong Hyeon Yoon-
dc.contributor.authorSeung-Min Lee-
dc.contributor.authorY Lee-
dc.contributor.authorMin Ju Kim-
dc.contributor.authorJae Won Yang-
dc.contributor.authorJeong Yi Choi-
dc.contributor.authorJu Yeon Kwak-
dc.contributor.authorKwang-Pyo Lee-
dc.contributor.authorYong Ryoul Yang-
dc.contributor.authorKi-Sun Kwon-
dc.date.accessioned2021-11-30T15:31:03Z-
dc.date.available2021-11-30T15:31:03Z-
dc.date.issued2022-
dc.identifier.issn0006291X-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/25067-
dc.description.abstractSarcopenia is the age-related loss of muscle mass and function and no pharmacological medication has been approved for its treatment. We established an atrogin-1/MAFbx promoter assay to find drug candidates that inhibit myotube atrophy. Alverine citrate (AC) was identified using high-throughput screening of an existing drug library. AC is an established medicine for stomach and intestinal spasms. AC treatment increased myotube diameter and inhibited atrophy signals induced by either C26-conditioned medium or dexamethasone in cultured C2C12 myoblasts. AC also enhanced myoblast fusion through the upregulation of fusion-related genes during C2C12 myoblast differentiation. Oral administration of AC improves muscle mass and physical performance in aged mice, as well as hindlimb-disused mice. Taken together, our data suggest that AC may be a novel therapeutic candidate for improving muscle weakness, including sarcopenia.-
dc.publisherElsevier-
dc.titleAlverine citrate promotes myogenic differentiation and ameliorates muscle atrophy-
dc.title.alternativeAlverine citrate promotes myogenic differentiation and ameliorates muscle atrophy-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number0-
dc.citation.endPage162-
dc.citation.startPage157-
dc.citation.volume586-
dc.contributor.affiliatedAuthorJong Hyeon Yoon-
dc.contributor.affiliatedAuthorSeung-Min Lee-
dc.contributor.affiliatedAuthorMin Ju Kim-
dc.contributor.affiliatedAuthorJae Won Yang-
dc.contributor.affiliatedAuthorJeong Yi Choi-
dc.contributor.affiliatedAuthorJu Yeon Kwak-
dc.contributor.affiliatedAuthorKwang-Pyo Lee-
dc.contributor.affiliatedAuthorYong Ryoul Yang-
dc.contributor.affiliatedAuthorKi-Sun Kwon-
dc.contributor.alternativeName윤종현-
dc.contributor.alternativeName이승민-
dc.contributor.alternativeName이영랑-
dc.contributor.alternativeName김민주-
dc.contributor.alternativeName양재원-
dc.contributor.alternativeName최정이-
dc.contributor.alternativeName곽주연-
dc.contributor.alternativeName이광표-
dc.contributor.alternativeName양용렬-
dc.contributor.alternativeName권기선-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 586, pp. 157-162-
dc.identifier.doi10.1016/j.bbrc.2021.11.076-
dc.subject.keywordAlverine citrate-
dc.subject.keywordSarcopenia-
dc.subject.keywordSkeletal muscle atrophy-
dc.subject.keywordAging-
dc.subject.localSarcopenia-
dc.subject.localAging-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Aging Research Center > 1. Journal Articles
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