Germinal center-induced immunity is correlated with protection against SARS-CoV-2 reinfection but not lung damage

Cited 6 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorGreen Kim-
dc.contributor.authorD H Kim-
dc.contributor.authorHanseul Oh-
dc.contributor.authorS Bae-
dc.contributor.authorJ Kwon-
dc.contributor.authorM J Kim-
dc.contributor.authorE Lee-
dc.contributor.authorEun-Ha Hwang-
dc.contributor.authorH Jung-
dc.contributor.authorBon-Sang Koo-
dc.contributor.authorSeung Ho Baek-
dc.contributor.authorPhil Yong Kang-
dc.contributor.authorYou Jung An-
dc.contributor.authorJ H Park-
dc.contributor.authorJ H Park-
dc.contributor.authorK S Lyoo-
dc.contributor.authorChoong-Min Ryu-
dc.contributor.authorS H Kim-
dc.contributor.authorJung Joo Hong-
dc.date.accessioned2021-12-06T15:30:26Z-
dc.date.available2021-12-06T15:30:26Z-
dc.date.issued2021-
dc.identifier.issn0022-1899-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/25080-
dc.description.abstractGerminal centers (GCs) elicit protective humoral immunity through a combination of antibody-secreting cells and memory B cells, following pathogen invasion or vaccination. However, the possibility of a GC response inducing protective immunity against reinfection following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unknown. We found GC activity was consistent with seroconversion observed in recovered macaques and humans. Rechallenge with a different clade of virus resulted in significant reduction in replicating virus titers in respiratory tracts in macaques with high GC activity. However, diffuse alveolar damage and increased fibrotic tissue were observed in lungs of reinfected macaques. Our study highlights the importance of GCs developed during natural SARS-CoV-2 infection in managing viral loads in subsequent infections. However, their ability to alleviate lung damage remains to be determined. These results may improve understanding of SARS-CoV-2-induced immune responses, resulting in better coronavirus disease 2019 (COVID-19) diagnosis, treatment, and vaccine development.-
dc.publisherOxford Univ Press-
dc.titleGerminal center-induced immunity is correlated with protection against SARS-CoV-2 reinfection but not lung damage-
dc.title.alternativeGerminal center-induced immunity is correlated with protection against SARS-CoV-2 reinfection but not lung damage-
dc.typeArticle-
dc.citation.titleJournal of Infectious Diseases-
dc.citation.number11-
dc.citation.endPage1872-
dc.citation.startPage1861-
dc.citation.volume224-
dc.contributor.affiliatedAuthorGreen Kim-
dc.contributor.affiliatedAuthorHanseul Oh-
dc.contributor.affiliatedAuthorEun-Ha Hwang-
dc.contributor.affiliatedAuthorBon-Sang Koo-
dc.contributor.affiliatedAuthorSeung Ho Baek-
dc.contributor.affiliatedAuthorPhil Yong Kang-
dc.contributor.affiliatedAuthorYou Jung An-
dc.contributor.affiliatedAuthorChoong-Min Ryu-
dc.contributor.affiliatedAuthorJung Joo Hong-
dc.contributor.alternativeName김그린-
dc.contributor.alternativeName김동호-
dc.contributor.alternativeName오한슬-
dc.contributor.alternativeName배성만-
dc.contributor.alternativeName권지수-
dc.contributor.alternativeName김민재-
dc.contributor.alternativeName이은영-
dc.contributor.alternativeName황은하-
dc.contributor.alternativeName정효인-
dc.contributor.alternativeName구본상-
dc.contributor.alternativeName백승호-
dc.contributor.alternativeName강필용-
dc.contributor.alternativeName안유정-
dc.contributor.alternativeName박재학-
dc.contributor.alternativeName박종환-
dc.contributor.alternativeName류광수-
dc.contributor.alternativeName류충민-
dc.contributor.alternativeName김성한-
dc.contributor.alternativeName홍정주-
dc.identifier.bibliographicCitationJournal of Infectious Diseases, vol. 224, no. 11, pp. 1861-1872-
dc.identifier.doi10.1093/infdis/jiab535-
dc.subject.keywordGerminal center-
dc.subject.keywordSARS-CoV-2-
dc.subject.keywordViral reinfection-
dc.subject.keywordLung damage-
dc.subject.localGerminal center-
dc.subject.localGerminal center (GC)-
dc.subject.localgerminal center-
dc.subject.localSARS-CoV-2-
dc.subject.localSARS-Cov-2-
dc.subject.localViral reinfection-
dc.subject.locallung damage-
dc.subject.localLung damage-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.