Topoisomerase IIIβ deficiency induces neuro-behavioral changes and brain connectivity alterations in mice

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dc.contributor.authorF U Rahman-
dc.contributor.authorYou-Rim Kim-
dc.contributor.authorEun-kyeung Kim-
dc.contributor.authorHae Rim Kim-
dc.contributor.authorSang Mi Cho-
dc.contributor.authorJin Soo Lee-
dc.contributor.authorS J Kim-
dc.contributor.authorK Araki-
dc.contributor.authorK Yamamura-
dc.contributor.authorMi Ni Lee-
dc.contributor.authorSeul Gi Park-
dc.contributor.authorWon Kee Yoon-
dc.contributor.authorKihoon Lee-
dc.contributor.authorYoung Suk Won-
dc.contributor.authorHyoung-Chin Kim-
dc.contributor.authorY Lee-
dc.contributor.authorH Y Lee-
dc.contributor.authorKi Hoan Nam-
dc.date.accessioned2021-12-07T15:30:23Z-
dc.date.available2021-12-07T15:30:23Z-
dc.date.issued2021-
dc.identifier.issn16616596-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/25084-
dc.description.abstractTopoisomerase IIIβ (Top3β), the only dual-activity topoisomerase in mammals that can change topology of both DNA and RNA, is known to be associated with neurodevelopment and mental dysfunction in humans. However, there is no report showing clear associations of Top3β with neuropsychiatric phenotypes in mice. Here, we investigated the effect of Top3β on neuro-behavior using newly generated Top3β deficient (Top3β-/-) mice. We found that Top3β-/- mice showed decreased anxiety and depression-like behaviors. The lack of Top3β was also associated with changes in circadian rhythm. In addition, a clear expression of Top3β was demonstrated in the central nervous system of mice. Positron emission tomography/computed tomography (PET/CT) analysis revealed significantly altered connectivity between many brain regions in Top3β-/- mice, including the connectivity between the olfactory bulb and the cerebellum, the connectivity between the amygdala and the olfactory bulb, and the connectivity between the globus pallidus and the optic nerve. These connectivity alterations in brain regions are known to be linked to neurodevelopmental as well as psychiatric and behavioral disorders in humans. Therefore, we conclude that Top3β is essential for normal brain function and behavior in mice and that Top3β could be an interesting target to study neuropsychiatric disorders in humans.-
dc.publisherMDPI-
dc.titleTopoisomerase IIIβ deficiency induces neuro-behavioral changes and brain connectivity alterations in mice-
dc.title.alternativeTopoisomerase IIIβ deficiency induces neuro-behavioral changes and brain connectivity alterations in mice-
dc.typeArticle-
dc.citation.titleInternational Journal of Molecular Sciences-
dc.citation.number23-
dc.citation.endPage12806-
dc.citation.startPage12806-
dc.citation.volume22-
dc.contributor.affiliatedAuthorYou-Rim Kim-
dc.contributor.affiliatedAuthorEun-kyeung Kim-
dc.contributor.affiliatedAuthorHae Rim Kim-
dc.contributor.affiliatedAuthorSang Mi Cho-
dc.contributor.affiliatedAuthorJin Soo Lee-
dc.contributor.affiliatedAuthorMi Ni Lee-
dc.contributor.affiliatedAuthorSeul Gi Park-
dc.contributor.affiliatedAuthorWon Kee Yoon-
dc.contributor.affiliatedAuthorKihoon Lee-
dc.contributor.affiliatedAuthorYoung Suk Won-
dc.contributor.affiliatedAuthorHyoung-Chin Kim-
dc.contributor.affiliatedAuthorKi Hoan Nam-
dc.contributor.alternativeNameRahman-
dc.contributor.alternativeName김유림-
dc.contributor.alternativeName김은경-
dc.contributor.alternativeName김해림-
dc.contributor.alternativeName조상미-
dc.contributor.alternativeName이진수-
dc.contributor.alternativeName김수진-
dc.contributor.alternativeNameAraki-
dc.contributor.alternativeNameYamamura-
dc.contributor.alternativeName이미니-
dc.contributor.alternativeName박슬기-
dc.contributor.alternativeName윤원기-
dc.contributor.alternativeName이기훈-
dc.contributor.alternativeName원영석-
dc.contributor.alternativeName김형진-
dc.contributor.alternativeName이영희-
dc.contributor.alternativeName이호영-
dc.contributor.alternativeName남기환-
dc.identifier.bibliographicCitationInternational Journal of Molecular Sciences, vol. 22, no. 23, pp. 12806-12806-
dc.identifier.doi10.3390/ijms222312806-
dc.subject.keywordTop3β-
dc.subject.keywordBrain connectivity-
dc.subject.keywordBehavioral impairments-
dc.subject.keywordAnxiety-
dc.subject.keywordDepression-
dc.subject.keywordCircadian activity-
dc.subject.keywordNeuropsychiatric disorders-
dc.subject.localAnxiety-
dc.subject.localDepression-
dc.description.journalClassY-
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Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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