Capsaicin inhibits HIF-1α accumulation through suppression of mitochondrial respiration in lung cancer cells

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Title
Capsaicin inhibits HIF-1α accumulation through suppression of mitochondrial respiration in lung cancer cells
Author(s)
Tae-Hee Han; Min Kyung Park; H Nakamura; Hyun Seung Ban
Bibliographic Citation
Biomedicine & Pharmacotherapy, vol. 146, pp. 112500-112500
Publication Year
2022
Abstract
Hypoxia inducible factor (HIF)-1α is an important transcription factor regulating cancer metabolism in hypoxic environment. Capsaicin is known to inhibit hypoxia-induced HIF activity in lung cancer. Hence, in this study we tried to elucidate its inhibitory mechanism of action. In lung cancer cells, including H1299, H23, A549, and H2009 cells, capsaicin inhibited cell growth and HIF activation. Under hypoxic conditions, capsaicin reduced the accumulation of HIF-1α protein and the expression of its target genes, including pyruvate dehydrogenase kinase 1 (PDK1) and glucose transporter 1 (GLUT1), with no effect on overall HIF-1α mRNA levels in the H1299 cells. In addition, capsaicin increased intracellular oxygen levels by suppressing mitochondrial respiration, resulting in a reduction of HIF-1α accumulation. Furthermore, mitochondrial ATP production was reduced by capsaicin through the inhibition of mitochondrial respiration in the H1299, H23, A549, and H2009 cells. These results indicate that capsaicin potentially exhibits anticancer therapeutic effects in lung cancer under hypoxic conditions.
Keyword
HypoxiaCapsaicinHIF-1αMitochondrial respirationLung cancer
ISSN
0753-3322
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.biopha.2021.112500
Type
Article
Appears in Collections:
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
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