DC Field | Value | Language |
---|---|---|
dc.contributor.author | J Shin | - |
dc.contributor.author | Jung Ran Noh | - |
dc.contributor.author | D Choe | - |
dc.contributor.author | N Lee | - |
dc.contributor.author | Y Song | - |
dc.contributor.author | S Cho | - |
dc.contributor.author | Eun Jung Kang | - |
dc.contributor.author | Min-Jeong Go | - |
dc.contributor.author | Seok-Kyun Ha | - |
dc.contributor.author | Dong-Ho Chang | - |
dc.contributor.author | Jae-Hoon Kim | - |
dc.contributor.author | Yong-Hoon Kim | - |
dc.contributor.author | Kyoung Shim Kim | - |
dc.contributor.author | Haiyoung Jung | - |
dc.contributor.author | Myung Hee Kim | - |
dc.contributor.author | Bong Hyun Sung | - |
dc.contributor.author | Seung Goo Lee | - |
dc.contributor.author | Dae Hee Lee | - |
dc.contributor.author | Byoung Chan Kim | - |
dc.contributor.author | Chul-Ho Lee | - |
dc.contributor.author | B K Cho | - |
dc.date.accessioned | 2021-12-16T15:30:23Z | - |
dc.date.available | 2021-12-16T15:30:23Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2049-2618 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/25140 | - |
dc.description.abstract | Background: The gut microbiota is associated with diverse age-related disorders. Several rejuvenation methods, such as probiotic administration and faecal microbiota transplantation, have been applied to alter the gut microbiome and promote healthy ageing. Nevertheless, prolongation of the health span of aged mice by remodelling the gut microbiome remains challenging. Results: Here, we report the changes in gut microbial communities and their functions in mouse models during ageing and three rejuvenation procedures including co-housing, serum-injection and parabiosis. Our results showed that the compositional structure and gene abundance of the intestinal microbiota changed dynamically during the ageing process. Through the three rejuvenation procedures, we observed that the microbial community and intestinal immunity of aged mice were comparable to those of young mice. The results of metagenomic data analysis underscore the importance of the high abundance of Akkermansia and the butyrate biosynthesis pathway in the rejuvenated mouse group. Furthermore, oral administration of Akkermansia sufficiently ameliorated the senescence-related phenotype in the intestinal systems in aged mice and extended the health span, as evidenced by the frailty index and restoration of muscle atrophy. Conclusions: In conclusion, the changes in key microbial communities and their functions during ageing and three rejuvenation procedures, and the increase in the healthy lifespan of aged mice by oral administration of Akkermansia. Our results provide a rationale for developing therapeutic strategies to achieve healthy active ageing. Video abstract. | - |
dc.publisher | Springer-BMC | - |
dc.title | Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing | - |
dc.title.alternative | Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing | - |
dc.type | Article | - |
dc.citation.title | Microbiome | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 240 | - |
dc.citation.startPage | 240 | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Jung Ran Noh | - |
dc.contributor.affiliatedAuthor | Eun Jung Kang | - |
dc.contributor.affiliatedAuthor | Min-Jeong Go | - |
dc.contributor.affiliatedAuthor | Seok-Kyun Ha | - |
dc.contributor.affiliatedAuthor | Dong-Ho Chang | - |
dc.contributor.affiliatedAuthor | Jae-Hoon Kim | - |
dc.contributor.affiliatedAuthor | Yong-Hoon Kim | - |
dc.contributor.affiliatedAuthor | Kyoung Shim Kim | - |
dc.contributor.affiliatedAuthor | Haiyoung Jung | - |
dc.contributor.affiliatedAuthor | Myung Hee Kim | - |
dc.contributor.affiliatedAuthor | Bong Hyun Sung | - |
dc.contributor.affiliatedAuthor | Seung Goo Lee | - |
dc.contributor.affiliatedAuthor | Dae Hee Lee | - |
dc.contributor.affiliatedAuthor | Byoung Chan Kim | - |
dc.contributor.affiliatedAuthor | Chul-Ho Lee | - |
dc.contributor.alternativeName | 신종오 | - |
dc.contributor.alternativeName | 노정란 | - |
dc.contributor.alternativeName | 최동휘 | - |
dc.contributor.alternativeName | 이남일 | - |
dc.contributor.alternativeName | 송요셉 | - |
dc.contributor.alternativeName | 조수형 | - |
dc.contributor.alternativeName | 강은정 | - |
dc.contributor.alternativeName | 고민정 | - |
dc.contributor.alternativeName | 하석균 | - |
dc.contributor.alternativeName | 장동호 | - |
dc.contributor.alternativeName | 김재훈 | - |
dc.contributor.alternativeName | 김용훈 | - |
dc.contributor.alternativeName | 김경심 | - |
dc.contributor.alternativeName | 정해용 | - |
dc.contributor.alternativeName | 김명희 | - |
dc.contributor.alternativeName | 성봉현 | - |
dc.contributor.alternativeName | 이승구 | - |
dc.contributor.alternativeName | 이대희 | - |
dc.contributor.alternativeName | 김병찬 | - |
dc.contributor.alternativeName | 이철호 | - |
dc.contributor.alternativeName | 조병관 | - |
dc.identifier.bibliographicCitation | Microbiome, vol. 9, pp. 240-240 | - |
dc.identifier.doi | 10.1186/s40168-021-01189-5 | - |
dc.subject.keyword | Ageing | - |
dc.subject.keyword | Rejuvenation | - |
dc.subject.keyword | Akkermansia muciniphila | - |
dc.subject.keyword | Shotgun metagenomics | - |
dc.subject.keyword | 16s rRNA sequencing | - |
dc.subject.local | ageing | - |
dc.subject.local | Ageing | - |
dc.subject.local | Rejuvenation | - |
dc.subject.local | rejuvenation | - |
dc.subject.local | Akkermansia muciniphila | - |
dc.subject.local | Shotgun metagenomics | - |
dc.subject.local | 16s rRNA sequencing | - |
dc.description.journalClass | Y | - |
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