Streptooctatins A and B, fusicoccane-type diterpenoids with autophagic activity from Streptomyces sp. KCB17JA11

Cited 0 time in scopus
Metadata Downloads
Title
Streptooctatins A and B, fusicoccane-type diterpenoids with autophagic activity from Streptomyces sp. KCB17JA11
Author(s)
Jun-Pil Jang; Mina Jang; Gui-Ja Hwang; Min Hee Kim; Jong Seog AhnSung-Kyun KoJae-Hyuk Jang
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 57, pp. 128504-128504
Publication Year
2022
Abstract
Two new fusicoccane-type diterpenoids, streptooctatins A (1) and B (2), together with a known compound cyclooctatin (3) were isolated from Streptomyces sp. KCB17JA11. The structures of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and HRESIMS experiments. Compounds 1 and 2 induced EGFP-LC3 puncta indicating autophagic activities against HeLa cells without cytotoxicity.
Keyword
Secondary metabolitesStreptomyces sp.Fusicoccane-type diterpenoidsAutophagy
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2021.128504
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.