Osteopontin is a biomarker for early autoimmune uveoretinitis

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Title
Osteopontin is a biomarker for early autoimmune uveoretinitis
Author(s)
J Kim; M Ahn; Y Choi; J Chun; Kyungsook Jung; A Tanaka; H Matsuda; T Shin
Bibliographic Citation
Neural Regeneration Research, vol. 17, no. 7, pp. 1604-1608
Publication Year
2022
Abstract
Osteopontin (OPN) is an extracellular matrix protein with a diverse range of functions, including roles in cell adhesion, migration, and immunomodulation, which are associated with the modulation of neuroinflammation in the central nervous system. The present study was performed to evaluate the involvement of OPN in the eyes of an experimental autoimmune uveoretinitis (EAU) model. The EAU model was developed by immunization of Lewis rats with interphotoreceptor retinoid-binding protein. The results showed the OPN level was remarkably upregulated in the eye of EAU rats on day 9 post-immunization. The level of CD44, a ligand of OPN, was increased in the ciliary body of EAU rats. Furthermore, OPN was also detected in the ciliary body and activated microglia/macrophages in the EAU retina. The results suggest that OPN was significantly upregulated in the eyes of EAU rats, and that it may be useful as an early biomarker of ocular autoimmune diseases. All animal experiments were approved by the Institutional Animal Care and Use Committee of Jeju National University (approval No. 2020-0012) on March 11, 2020.
Keyword
CD44Ciliary bodyExperimental autoimmune uveoretinitisMacrophageMuller cellOsteopontinPhotoreceptor cellRetina
ISSN
1673-5374
Publisher
Kluwer
DOI
http://dx.doi.org/10.4103/1673-5374.330614
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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