Thiolactomide: a new homocysteine thiolactone derivative from Streptomyces sp. with neuroprotective activity
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jun-Pil Jang | - |
| dc.contributor.author | Min Cheol Kwon | - |
| dc.contributor.author | T Nogawa | - |
| dc.contributor.author | S Takahashi | - |
| dc.contributor.author | H Osada | - |
| dc.contributor.author | Jong Seog Ahn | - |
| dc.contributor.author | Sung-Kyun Ko | - |
| dc.contributor.author | Jae-Hyuk Jang | - |
| dc.date.accessioned | 2021-12-27T15:30:34Z | - |
| dc.date.available | 2021-12-27T15:30:34Z | - |
| dc.date.issued | 2021 | - |
| dc.identifier.issn | 1017-7825 | - |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/25181 | - |
| dc.description.abstract | A new homocysteine thiolactone derivative, thiolactomide (1), was isolated along with a known compound, N-acetyl homocysteine thiolactone (2), from a culture extract of soil-derived Streptomyces sp. RK88-1441. The structures of these compounds were elucidated by detailed NMR and MS spectroscopic analyses with literature study. Biological evaluation studies revealed that both 1 and 2 exhibit neuroprotective activity against 6-hydroxydopamine (6-OHDA) mediated neurotoxicity by blocking generation of hydrogen peroxide in neuroblastoma SH-SY5Y cells. | - |
| dc.publisher | Korea Soc-Assoc-Inst | - |
| dc.title | Thiolactomide: a new homocysteine thiolactone derivative from Streptomyces sp. with neuroprotective activity | - |
| dc.title.alternative | Thiolactomide: a new homocysteine thiolactone derivative from Streptomyces sp. with neuroprotective activity | - |
| dc.type | Article | - |
| dc.citation.title | Journal of Microbiology and Biotechnology | - |
| dc.citation.number | 12 | - |
| dc.citation.endPage | 1671 | - |
| dc.citation.startPage | 1667 | - |
| dc.citation.volume | 31 | - |
| dc.contributor.affiliatedAuthor | Jun-Pil Jang | - |
| dc.contributor.affiliatedAuthor | Min Cheol Kwon | - |
| dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
| dc.contributor.affiliatedAuthor | Sung-Kyun Ko | - |
| dc.contributor.affiliatedAuthor | Jae-Hyuk Jang | - |
| dc.contributor.alternativeName | 장준필 | - |
| dc.contributor.alternativeName | 권민철 | - |
| dc.contributor.alternativeName | Nogawa | - |
| dc.contributor.alternativeName | Takahashi | - |
| dc.contributor.alternativeName | Osada | - |
| dc.contributor.alternativeName | 안종석 | - |
| dc.contributor.alternativeName | 고성균 | - |
| dc.contributor.alternativeName | 장재혁 | - |
| dc.identifier.bibliographicCitation | Journal of Microbiology and Biotechnology, vol. 31, no. 12, pp. 1667-1671 | - |
| dc.identifier.doi | 10.4014/jmb.2108.08015 | - |
| dc.subject.keyword | Thiolactomide | - |
| dc.subject.keyword | Streptomyces sp. | - |
| dc.subject.keyword | N-acetyl homocysteine thiolactone | - |
| dc.subject.keyword | Neuroprotective activity | - |
| dc.subject.keyword | 6-hydroxydopamine | - |
| dc.subject.local | Thiolactomide | - |
| dc.subject.local | Streptomyces sp | - |
| dc.subject.local | Streptomyces sp. | - |
| dc.subject.local | streptomyces sp. | - |
| dc.subject.local | N-acetyl homocysteine thiolactone | - |
| dc.subject.local | Neuroprotective activity | - |
| dc.subject.local | 6-hydroxydopamine | - |
| dc.subject.local | 6-Hydroxydopamine | - |
| dc.description.journalClass | Y | - |
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- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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