Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny

Cited 18 time in scopus
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Title
Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
Author(s)
Bohyeon Jeong; Jeong Yeob Baek; Jahong Koo; Subin Park; Young-Kyoung Ryu; Kyoung Shim Kim; S Zhang; C Chung; R Dogan; H S Choi; D Um; T K Kim; Wang Sik Lee; Jinyoung Jeong; W H Shin; Jae-Ran LeeNam-Soon KimDa Yong Lee
Bibliographic Citation
Journal of Hazardous Materials, vol. 426, pp. 127815-127815
Publication Year
2022
Abstract
As global plastic production continues to grow, microplastics released from a massive quantity of plastic wastes have become a critical environmental concern. These microplastic particles are found in a wide range of living organisms in a diverse array of ecosystems. In this study, we investigated the biological effects of polystyrene nanoplastic (PSNP) on development of the central nervous system using cultured neural stem cells (NSCs) and mice exposed to PSNP during developmental stages. Our study demonstrates that maternal administration of PSNP during gestation and lactating periods altered the functioning of NSCs, neural cell compositions, and brain histology in progeny. Similarly, PSNP-induced molecular and functional defects were also observed in cultured NSCs in vitro. Finally, we show that the abnormal brain development caused by exposure to high concentrations of PSNP results in neurophysiological and cognitive deficits in a gender-specific manner. Our data demonstrate the possibility that exposure to high amounts of PSNP may increase the risk of neurodevelopmental defects.
Keyword
Polystyrene nanoplasticGenerational transferNeurodevelopmental defectsNeural stem cellCognitive deficit
ISSN
0304-3894
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.jhazmat.2021.127815
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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