Streptoglycerides E-H, unsaturated polyketides from the marine-derived bacterium Streptomyces specialis and their anti-inflammatory activity

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Title
Streptoglycerides E-H, unsaturated polyketides from the marine-derived bacterium Streptomyces specialis and their anti-inflammatory activity
Author(s)
H J Shin; C S Heo; C V Anh; Yeo Dae YoonJong Soon Kang
Bibliographic Citation
Marine Drugs, vol. 20, no. 1, pp. 44-44
Publication Year
2022
Abstract
Four new streptoglycerides E?H (1?4), with a rare 6/5/5/-membered ring system, were isolated from a marine-derived actinomycete Streptomyces specialis. The structures of 1?4 were elucidated by detailed analysis of HRESIMS, 1D and 2D NMR data and ECD spectra as well as comparison of their spectroscopic data with those reported in literature. Compounds 1?4 showed significant anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production in Raw 264.7 cells with IC50 values ranging from 3.5 to 10.9 μM. Especially, 2 suppressed mRNA expression levels of iNOS and IL-6 without cytotoxicity.
Keyword
Marine-derived bacteriumStreptomyces specialisStreptoglyceridesAnti-inflammatory
ISSN
1660-3397
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/md20010044
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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