Antibacterial and cytotoxic phenolic polyketides from two marine-derived fungal strains of Aspergillus unguis

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Title
Antibacterial and cytotoxic phenolic polyketides from two marine-derived fungal strains of Aspergillus unguis
Author(s)
C V Anh; Joo Hee KwonJong Soon Kang; H S Lee; C S Heo; H J Shin
Bibliographic Citation
Pharmaceuticals, vol. 15, no. 1, pp. 74-74
Publication Year
2022
Abstract
A chemical investigation on the EtOAc extracts from two marine-derived fungal strains of Aspergillus unguis resulted in the isolation of three previously undescribed phenolic polyketides including unguidepside C (1), aspersidone B (3), and agonodepside C (12), and their 14 known congeners. The structures of the new compounds were determined based on detailed analysis and comparison of their spectroscopic data with literature values, as well as Snatzke's method. The new compounds (1, 3, and 12) displayed a significant anti-Gram-positive bacterial activity, with MIC values ranging from 5.3 to 22.1 μM. Additionally, the isolated compounds (1-11 and 13-16) were evaluated for their cytotoxicity against a panel of tumor cell lines. Most of them (except for 9) displayed cytotoxicity against all the tested cell lines, with IC50 values ranging from 2.5 to 46.9 μM.
Keyword
Aspergillus unguisMarine-derived fungusPhenolic polyketidesAntibacterialCytotoxicity
ISSN
1424-8247
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/ph15010074
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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