Different phases of aging in mouse old skeletal muscle

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dc.contributor.authorYong-Kook Kang-
dc.contributor.authorByungku Min-
dc.contributor.authorJaemin Eom-
dc.contributor.authorJung Sun Park-
dc.date.accessioned2022-01-27T15:30:23Z-
dc.date.available2022-01-27T15:30:23Z-
dc.date.issued2022-
dc.identifier.issn1945-4589-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/25351-
dc.description.abstractWith a graying population and increasing longevity, it is essential to identify life transition in later years and discern heterogeneity among older people. Subclassifying the elderly population to inspect the subdivisions for pathophysiological differences is particularly important for the investigation of age-related illnesses. For this purpose, using 24- and 28-month-old mice to represent the "young-old" and "old-old", respectively, we compared their skeletal muscle transcriptomes and found each in a distinct stage: early/gradual (E-aging) and late/accelerated aging phase (L-aging). Principal component analysis showed that the old-old transcriptomes were largely disengaged from the forward transcriptomic trajectory generated in the younger-aged group, indicating a substantial change in gene expression profiles during L-aging. By calculating the transcriptomic distance, it was found that the 28-month group was closer to the two-month group than to the 24-month group. The divergence rate per month for the transcriptomes was the highest in L-aging, twice as fast as the rate in E-aging. Indeed, many of the L-aging genes were significantly altered in transcription, although the changes did not seem random but rather coordinated in a variety of functional gene sets. Of 2,707 genes transcriptionally altered during E-aging, two-thirds were also significantly changed during L-aging, to either downturning or upturning way. The downturn genes were related to mitochondrial function and translational gene sets, while the upturn genes were linked to inflammation-associated gene sets. Our results provide a transcriptomic muscle signature that distinguishes old-old mice from young-old mice. This can help to methodically examine muscle disorders in the elderly.-
dc.publisherImpact Journals Llc-
dc.titleDifferent phases of aging in mouse old skeletal muscle-
dc.title.alternativeDifferent phases of aging in mouse old skeletal muscle-
dc.typeArticle-
dc.citation.titleAging-US-
dc.citation.number1-
dc.citation.endPage160-
dc.citation.startPage143-
dc.citation.volume14-
dc.contributor.affiliatedAuthorYong-Kook Kang-
dc.contributor.affiliatedAuthorByungku Min-
dc.contributor.affiliatedAuthorJaemin Eom-
dc.contributor.affiliatedAuthorJung Sun Park-
dc.contributor.alternativeName강용국-
dc.contributor.alternativeName민병국-
dc.contributor.alternativeName엄재민-
dc.contributor.alternativeName박정선-
dc.identifier.bibliographicCitationAging-US, vol. 14, no. 1, pp. 143-160-
dc.identifier.doi10.18632/aging.203812-
dc.subject.keywordSkeletal muscle-
dc.subject.keywordEarly and late phase aging-
dc.subject.keywordTranscriptome-
dc.subject.keywordYoung-old-
dc.subject.keywordOld-old-
dc.subject.localskeletal muscle-
dc.subject.localSkeletal muscle-
dc.subject.localEarly and late phase aging-
dc.subject.localTranscriptomes-
dc.subject.localtranscriptome-
dc.subject.localTranscriptome-
dc.subject.localYoung-old-
dc.subject.localOld-old-
dc.description.journalClassY-
Appears in Collections:
Aging Convergence Research Center > 1. Journal Articles
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