Lifespan extension and anti-oxidant effects of carotenoid pigments in Caenorhabditis elegans

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Title
Lifespan extension and anti-oxidant effects of carotenoid pigments in Caenorhabditis elegans
Author(s)
Sang Ah Lee; W H Lim; Ve Van Le; So-Ra Ko; B Kim; Hee-Mock OhChi-Yong Ahn
Bibliographic Citation
Bioresource Technology Reports, vol. 17, pp. 100962-100962
Publication Year
2022
Abstract
Haematococcus lacustris is a green unicellular alga known for its diverse beneficial carotenoids, such as β-carotene, canthaxanthin, and astaxanthin, with varying compositions at different morphological stages. Each carotenoid might affect the lifespan of Caenorhabditis elegans by inhibiting reactive oxygen species (ROS). C. elegans were fed with carotenoids either using the Escherichia coli OP50 that had pre-consumed commercial carotenoids and the optimal Haematococcus medium containing a dissolved carotenoid. As a result, lifespan of C. elegans was extended by 1.3 times. Three carotenoids indirectly protected C. elegans against ROS by upregulating the expression of superoxide dismutase (maximum 9.8 times) and catalase (maximum 2.5 times). Carotenoids reduced the concentration of malondialdehyde, a product of lipid peroxidation induced by ROS, by 11.2 times in C. elegans. These results suggest that carotenoids could induce antioxidation effect and prolong the lifespan of C. elegans. And H. lacustris could be the most versatile producer of carotenoids.
Keyword
Haematococcus lacustrisCarotenoidsCaenorhabditis elegansLifespanAntioxidation
ISSN
2589-014X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.biteb.2022.100962
Type
Article
Appears in Collections:
Synthetic Biology and Bioengineering Research Institute > Cell Factory Research Center > 1. Journal Articles
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