Light-stimulated carbon dot hydrogel: targeting and clearing infectious bacteria in vivo

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dc.contributor.authorC H Lee-
dc.contributor.authorSeuk Young Song-
dc.contributor.authorY J Chung-
dc.contributor.authorEun Kyoung Choi-
dc.contributor.authorJ Jang-
dc.contributor.authorD H Lee-
dc.contributor.authorHae Dong Kim-
dc.contributor.authorDong Uk Kim-
dc.contributor.authorC B Park-
dc.date.accessioned2022-02-22T15:30:59Z-
dc.date.available2022-02-22T15:30:59Z-
dc.date.issued2022-
dc.identifier.issn2576-6422-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/25461-
dc.description.abstractInfectious bacteria evolve fast into resistance to conventional antimicrobial agents, whereas treatments for drug resistance bacteria progress more slowly. Here, we report a universally applicable photoactivated antimicrobial modality through light-responsive carbon dot-embedding soft hyaluronic acid hydrogel (CDgel). Because of the innate nature of the infectious bacteria that produce hyaluronidase, applied hyaluronic acid-based CDgel breaks down via bacteria and releases carbon dots (CDs) into the infectious sites. The released CDs possess photodynamic capabilities under light irradiation, inducing 1O2 generation and growth inhibition of the infectious bacteria, S. aureus and E. coli (∼99% and ∼97%, respectively), in vitro. In particular, these photodynamic effects of CDs from CDgel have been shown to accelerate the healing of infected wounds in vivo, showing a higher wound regeneration rate as compared to that of untreated wounds. Our work demonstrates that the biocompatible and shape-controllable CDgel possesses therapeutic potential as a treatment modality for the light-driven control of drug-resistant bacterial infections.-
dc.publisherAmer Chem Soc-
dc.titleLight-stimulated carbon dot hydrogel: targeting and clearing infectious bacteria in vivo-
dc.title.alternativeLight-stimulated carbon dot hydrogel: targeting and clearing infectious bacteria in vivo-
dc.typeArticle-
dc.citation.titleACS Applied Bio Materials-
dc.citation.number2-
dc.citation.endPage770-
dc.citation.startPage761-
dc.citation.volume5-
dc.contributor.affiliatedAuthorSeuk Young Song-
dc.contributor.affiliatedAuthorEun Kyoung Choi-
dc.contributor.affiliatedAuthorHae Dong Kim-
dc.contributor.affiliatedAuthorDong Uk Kim-
dc.contributor.alternativeName이창헌-
dc.contributor.alternativeName송석영-
dc.contributor.alternativeName정유정-
dc.contributor.alternativeName최은경-
dc.contributor.alternativeName장진형-
dc.contributor.alternativeName이대헌-
dc.contributor.alternativeName김해동-
dc.contributor.alternativeName김동욱-
dc.contributor.alternativeName박찬범-
dc.identifier.bibliographicCitationACS Applied Bio Materials, vol. 5, no. 2, pp. 761-770-
dc.identifier.doi10.1021/acsabm.1c01157-
dc.subject.keywordCarbon dot-
dc.subject.keywordPhotoablation-
dc.subject.keywordHydrogel-
dc.subject.keywordInfectious disease-
dc.subject.keywordAntibacterial-
dc.subject.keywordWound healing-
dc.subject.localCarbon dot-
dc.subject.localPhotoablation-
dc.subject.localHydrogel-
dc.subject.localHydrogels-
dc.subject.localhydrogel-
dc.subject.localhydrogels-
dc.subject.localinfectious disease-
dc.subject.localInfectious diseases-
dc.subject.localinfectious diseaese-
dc.subject.localInfectious disease-
dc.subject.localInfectious Disease-
dc.subject.localAntibacterial-
dc.subject.localAntibacterials-
dc.subject.localantibacterial-
dc.subject.localAnti-bacterial-
dc.subject.localantibacterials-
dc.subject.localwound healing-
dc.subject.localWound healing-
dc.description.journalClassN-
Appears in Collections:
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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