RK-270D and E, oxindole derivatives from Streptomyces sp. with anti-angiogenic activity
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jun-Pil Jang | - |
| dc.contributor.author | Mina Jang | - |
| dc.contributor.author | T Nogawa | - |
| dc.contributor.author | S Takahashi | - |
| dc.contributor.author | H Osada | - |
| dc.contributor.author | Jong Seog Ahn | - |
| dc.contributor.author | Sung-Kyun Ko | - |
| dc.contributor.author | Jae-Hyuk Jang | - |
| dc.date.accessioned | 2022-03-24T15:31:47Z | - |
| dc.date.available | 2022-03-24T15:31:47Z | - |
| dc.date.issued | 2022 | - |
| dc.identifier.issn | 1017-7825 | - |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/25637 | - |
| dc.description.abstract | A chemical investigation of a culture extract from Streptomyces sp. RK85-270 led to the isolation and characterization of two new oxindoles, RK-270D (1) and E (2). The structure of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and HRESIMS experiments. Compound 1 exhibited anti-angiogenic activities against human umbilical vein endothelial cells (HUVECs) without cytotoxicity. Results of Western blot analysis revealed that 1 inhibits VEGF-induced angiogenesis in the HUVECs via VEGFR2/ p38 MAPK-mediated pathway. | - |
| dc.publisher | Korea Soc-Assoc-Inst | - |
| dc.title | RK-270D and E, oxindole derivatives from Streptomyces sp. with anti-angiogenic activity | - |
| dc.title.alternative | RK-270D and E, oxindole derivatives from Streptomyces sp. with anti-angiogenic activity | - |
| dc.type | Article | - |
| dc.citation.title | Journal of Microbiology and Biotechnology | - |
| dc.citation.number | 3 | - |
| dc.citation.endPage | 306 | - |
| dc.citation.startPage | 302 | - |
| dc.citation.volume | 32 | - |
| dc.contributor.affiliatedAuthor | Jun-Pil Jang | - |
| dc.contributor.affiliatedAuthor | Mina Jang | - |
| dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
| dc.contributor.affiliatedAuthor | Sung-Kyun Ko | - |
| dc.contributor.affiliatedAuthor | Jae-Hyuk Jang | - |
| dc.contributor.alternativeName | 장준필 | - |
| dc.contributor.alternativeName | 장민아 | - |
| dc.contributor.alternativeName | Nogawa | - |
| dc.contributor.alternativeName | Takahashi | - |
| dc.contributor.alternativeName | Osada | - |
| dc.contributor.alternativeName | 안종석 | - |
| dc.contributor.alternativeName | 고성균 | - |
| dc.contributor.alternativeName | 장재혁 | - |
| dc.identifier.bibliographicCitation | Journal of Microbiology and Biotechnology, vol. 32, no. 3, pp. 302-306 | - |
| dc.identifier.doi | 10.4014/jmb.2110.10039 | - |
| dc.subject.keyword | Oxindole | - |
| dc.subject.keyword | Streptomyces sp. | - |
| dc.subject.keyword | Structural elucidation | - |
| dc.subject.keyword | Anti-angiogenic activity | - |
| dc.subject.local | Oxindoles | - |
| dc.subject.local | Oxindole | - |
| dc.subject.local | Streptomyces sp | - |
| dc.subject.local | Streptomyces sp. | - |
| dc.subject.local | streptomyces sp. | - |
| dc.subject.local | Structural elucidation | - |
| dc.subject.local | Antiangiogenic activity | - |
| dc.subject.local | anti-angiogenic activity | - |
| dc.subject.local | Anti-angiogenic activity | - |
| dc.description.journalClass | Y | - |
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- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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