RK-270D and E, oxindole derivatives from Streptomyces sp. with anti-angiogenic activity

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dc.contributor.authorJun-Pil Jang-
dc.contributor.authorMina Jang-
dc.contributor.authorT Nogawa-
dc.contributor.authorS Takahashi-
dc.contributor.authorH Osada-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorSung-Kyun Ko-
dc.contributor.authorJae-Hyuk Jang-
dc.date.accessioned2022-03-24T15:31:47Z-
dc.date.available2022-03-24T15:31:47Z-
dc.date.issued2022-
dc.identifier.issn1017-7825-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/25637-
dc.description.abstractA chemical investigation of a culture extract from Streptomyces sp. RK85-270 led to the isolation and characterization of two new oxindoles, RK-270D (1) and E (2). The structure of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and HRESIMS experiments. Compound 1 exhibited anti-angiogenic activities against human umbilical vein endothelial cells (HUVECs) without cytotoxicity. Results of Western blot analysis revealed that 1 inhibits VEGF-induced angiogenesis in the HUVECs via VEGFR2/ p38 MAPK-mediated pathway.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleRK-270D and E, oxindole derivatives from Streptomyces sp. with anti-angiogenic activity-
dc.title.alternativeRK-270D and E, oxindole derivatives from Streptomyces sp. with anti-angiogenic activity-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number3-
dc.citation.endPage306-
dc.citation.startPage302-
dc.citation.volume32-
dc.contributor.affiliatedAuthorJun-Pil Jang-
dc.contributor.affiliatedAuthorMina Jang-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.affiliatedAuthorSung-Kyun Ko-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.alternativeName장준필-
dc.contributor.alternativeName장민아-
dc.contributor.alternativeNameNogawa-
dc.contributor.alternativeNameTakahashi-
dc.contributor.alternativeNameOsada-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeName고성균-
dc.contributor.alternativeName장재혁-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 32, no. 3, pp. 302-306-
dc.identifier.doi10.4014/jmb.2110.10039-
dc.subject.keywordOxindole-
dc.subject.keywordStreptomyces sp.-
dc.subject.keywordStructural elucidation-
dc.subject.keywordAnti-angiogenic activity-
dc.subject.localOxindole-
dc.subject.localStreptomyces sp-
dc.subject.localStreptomyces sp.-
dc.subject.localstreptomyces sp.-
dc.subject.localStructural elucidation-
dc.subject.localAnti-angiogenic activity-
dc.subject.localanti-angiogenic activity-
dc.subject.localAntiangiogenic activity-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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