Nitrogen-containing secondary metabolites from a deep-sea fungus Aspergillus unguis and their anti-inflammatory activity

Cited 6 time in scopus
Metadata Downloads
Title
Nitrogen-containing secondary metabolites from a deep-sea fungus Aspergillus unguis and their anti-inflammatory activity
Author(s)
C V Anh; Yeo Dae YoonJong Soon Kang; H S Lee; C S Heo; H J Shin
Bibliographic Citation
Marine Drugs, vol. 20, no. 3, pp. 217-217
Publication Year
2022
Abstract
Aspergillus is well-known as the second-largest contributor of fungal natural products. Based on NMR guided isolation, three nitrogen-containing secondary metabolites, including two new compounds, variotin B (1) and coniosulfide E (2), together with a known compound, unguisin A (3), were isolated from the ethyl acetate (EtOAc) extract of the deep-sea fungus Aspergillus unguis IV17-109. The planar structures of 1 and 2 were elucidated by an extensive analysis of their spectroscopic data (HRESIMS, 1D and 2D NMR). The absolute configuration of 2 was determined by comparison of its optical rotation value with those of the synthesized analogs. Compound 2 is a rare, naturally occurring substance with an unusual cysteinol moiety. Furthermore, 1 showed moderate anti-inflammatory activity with an IC50 value of 20.0 μM. These results revealed that Aspergillus unguis could produce structurally diverse nitrogenous secondary metabolites, which can be used for further studies to find anti-inflammatory leads.
Keyword
Deep-sea fungusA. unguisVariotinConiosulfideAnti-inflammatory
ISSN
1660-3397
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/md20030217
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.