Amentoflavone-enriched Selaginella rossii Warb. suppresses body weight and hyperglycemia by inhibiting intestinal lipid absorption in mice fed a high-fat diet

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dc.contributor.authorHwa Lee-
dc.contributor.authorSeona Cho-
dc.contributor.authorSoo Yong Kim-
dc.contributor.authorJeongha Ju-
dc.contributor.authorSang Woo Lee-
dc.contributor.authorSangho Choi-
dc.contributor.authorH Li-
dc.contributor.authorR Piao-
dc.contributor.authorHo Yong Park-
dc.contributor.authorTae Sook Jeong-
dc.date.accessioned2022-04-01T15:31:27Z-
dc.date.available2022-04-01T15:31:27Z-
dc.date.issued2022-
dc.identifier.issn20751729-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/25680-
dc.description.abstractMany Selaginellaceae species are used as traditional medicines in Asia. This study is the first to investigate the anti-obesity and anti-diabetic effects of Selaginella rossii (SR) in high-fat diet (HFD)?fed C57BL/6J mice. Seven-day oral administration of ethanol extract (100 mg/kg/day) or ethyl acetate (EtOAc) extract (50 mg/kg/day) from SR improved oral fat tolerance by inhibiting intestinal lipid absorption; 10-week long-term administration of the EtOAc extract markedly reduced HFD-induced body weight gain and hyperglycemia by reducing adipocyte hypertrophy, glucose levels, HbA1c, and plasma insulin levels. Treatment with SR extracts reduced the expression of intestinal lipid absorption-related genes, including Cd36, fatty acid-binding protein 6, ATP-binding cassette subfamily G member 8, NPC1 like intracellular cholesterol transporter 1, and ATP-binding cassette subfamily A member 1. In addition, the EtOAc extract increased the expression of protein absorption?related solute carrier family genes, including Slc15a1, Slc8a2, and Slc6a9. SR extracts reduced HFD-induced hepatic steatosis by suppressing fatty acid transport to hepatocytes and hepatic lipid accumulation. Furthermore, amentoflavone (AMF), the primary compound in SR extracts, reduced intestinal lipid absorption by inhibiting fatty acid transport in HFD-fed mice. AMF-enriched SR extracts effectively protected against HFD-induced body weight gain and hyperglycemia by inhibiting intestinal lipid absorption.-
dc.publisherMDPI-
dc.titleAmentoflavone-enriched Selaginella rossii Warb. suppresses body weight and hyperglycemia by inhibiting intestinal lipid absorption in mice fed a high-fat diet-
dc.title.alternativeAmentoflavone-enriched Selaginella rossii Warb. suppresses body weight and hyperglycemia by inhibiting intestinal lipid absorption in mice fed a high-fat diet-
dc.typeArticle-
dc.citation.titleLife-Basel-
dc.citation.number4-
dc.citation.endPage472-
dc.citation.startPage472-
dc.citation.volume12-
dc.contributor.affiliatedAuthorHwa Lee-
dc.contributor.affiliatedAuthorSeona Cho-
dc.contributor.affiliatedAuthorSoo Yong Kim-
dc.contributor.affiliatedAuthorJeongha Ju-
dc.contributor.affiliatedAuthorSang Woo Lee-
dc.contributor.affiliatedAuthorSangho Choi-
dc.contributor.affiliatedAuthorHo Yong Park-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName이화-
dc.contributor.alternativeName조선아-
dc.contributor.alternativeName김수용-
dc.contributor.alternativeName주정하-
dc.contributor.alternativeName이상우-
dc.contributor.alternativeName최상호-
dc.contributor.alternativeNameLi-
dc.contributor.alternativeNamePiao-
dc.contributor.alternativeName박호용-
dc.contributor.alternativeName정태숙-
dc.identifier.bibliographicCitationLife-Basel, vol. 12, no. 4, pp. 472-472-
dc.identifier.doi10.3390/life12040472-
dc.subject.keywordSelaginella rossii-
dc.subject.keywordLipid absorption-
dc.subject.keywordHyperglycemia-
dc.subject.keywordAmentoflavone-
dc.subject.keywordFatty acid transport-
dc.subject.localSelaginella rossii-
dc.subject.localLipid absorption-
dc.subject.localhyperglycemia-
dc.subject.localHyperglycemia-
dc.subject.localAmentoflavone-
dc.subject.localamentoflavone-
dc.subject.localFatty acid transport-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > International Biological Material Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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