Antioxidant capacity of Potentilla paradoxa Nutt. and its beneficial effects related to anti-aging in HaCaT and B16F10 cells

Cited 4 time in scopus
Metadata Downloads
Title
Antioxidant capacity of Potentilla paradoxa Nutt. and its beneficial effects related to anti-aging in HaCaT and B16F10 cells
Author(s)
H P Lee; D S Kim; S H Park; C Y Shin; J J Woo; J W Kim; R B An; Changyoung Lee; J Y Cho
Bibliographic Citation
Plants-Basel, vol. 11, no. 7, pp. 873-873
Publication Year
2022
Abstract
Skin aging is a natural process influenced by intrinsic and extrinsic factors, and many skin anti?aging strategies have been developed. Plants from the genus Potentilla has been used in Europe and Asia to treat various diseases. Potentilla paradoxa Nutt. has been used as a traditional medicinal herb in China and has recently been shown to have anti?inflammatory effects. Despite the biological and pharmacological potential of Potentilla paradoxa Nutt., its skin anti?aging effects remain unclear. Therefore, this study evaluated the free radical scavenging, moisturizing, anti?melanogenic, and wound?healing effects of an ethanol extract of Potentilla paradoxa Nutt. (Pp?EE). Pp?EE was found to contain phenolics and flavonoids and exhibits in vitro antioxidant activities. α?Linolenic acid was found to be a major component of Pp?EE on gas chromatography?mass spectrometry. Pp?EE promoted the expression of hyaluronic acid (HA) synthesis?related enzymes and suppressed the expression of HA degradation?related enzymes in keratinocytes, so it may increase skin hydration. Pp?EE also showed inhibitory effects on the production and secretion of melanin in melanocytes. In a scratch assay, Pp?EE improved skin wound healing. Taken together, Pp?EE has several effects that may delay skin aging, suggesting its potential benefits as a natural ingredient in cosmetic or pharmaceutical products.
Keyword
Potentilla paradoxa Nutt.Antioxidant capacityMoisturizingAnti-melanogenesisWound healing
ISSN
2223-7747
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/plants11070873
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > International Biological Material Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.