Functional role of a novel algicidal compound produced by Pseudoruegeria sp. M32A2M on the harmful algae Alexandrium catenella

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Title
Functional role of a novel algicidal compound produced by Pseudoruegeria sp. M32A2M on the harmful algae Alexandrium catenella
Author(s)
So-Ra Ko; Y Jeong; S H Cho; E Lee; B S Jeong; S H Baek; B H Oh; Chi-Yong AhnHee-Mock Oh; B K Cho; S Cho
Bibliographic Citation
Chemosphere, vol. 300, pp. 134535-134535
Publication Year
2022
Abstract
A marine phytoplankton dinoflagellate, Alexandrium sp. is known to cause worldwide harmful algal blooms, resulting in paralytic shellfish poisoning. In this study, we isolated a novel compound secreted by the marine bacterium Pseudoruegeria sp. M32A2M, and showed that it displays algicidal activity against A. catenella (group I). The molecular structure of the compound was analyzed by using 1H nuclear magnetic resonance (NMR), 13C NMR, and gas chromatography-mass spectrometry, which revealed that the compound was a diketopiperazine, cyclo[Ala-Gly]. Cyclo[Ala-Gly] induced a rapid decrease in the active chlorophyll a content and maximal quantum yield of photosystem II, leading to membrane disintegration after 24 h of its treatment. It showed the highest algicidal effect against diketopiperazines and also showed specific algicidal activities against several dinoflagellate species, but not for diatom species. In particular, cyclo[Ala-Gly] caused the transcriptional downregulation of the photosynthesis-related membrane complex in A. catenella, but not in the diatom Chaetoceros simplex. Based on structural modeling, we elucidated that cyclo[Ala-Gly] has a structure similar to that of plastoquinone, which transfers electrons by binding to the photosystem II core proteins PsbA and PsbD. This suggests a novel role for cyclo[Ala-Gly] as a potential inhibitor of photosynthesis.
Keyword
AlgicidesHarmful algaeAlexandrium catenellaAlgicidal bacteriaHarmful algal bloom
ISSN
0045-6535
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.chemosphere.2022.134535
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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