펩타이드 혼성체를 사용한 배향성이 조절된 항체 단분자막의 제조방법

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Title
펩타이드 혼성체를 사용한 배향성이 조절된 항체 단분자막의 제조방법
Alternative Title
Method for preparing antibody monolayers which have controlled orientation using peptide hybrid
Inventor(s)
정봉현; 정상전; 이정민; 강효진; 정용원
Assignee(s)
한국생명공학연구원(소)
Application No.
12/679,982 (2010.03.25)
Registration No.
8,236,509 (2012.08.07)
Country
미국
Abstract
The present invention relates to a method for preparing an protein monolayer using a peptide hybrid for protein immobilization, more precisely a peptide hybrid for protein immobilization which has improved solubility by introducing a PEG linker and a proper reaction group to the oligopeptide having specific affinity to selected types of proteins and is designed to provide enough space between solid substrates and proteins immobilized, whereby various solid substrates treated by the hybrid catch specific proteins effectively on. The peptide hybrid for protein immobilization of the present invention facilitates the control of orientation of an antibody on various solid surfaces and immobilization of various antibodies of different origins or having different isotypes with different affinity. Therefore, the surface treatment technique using the peptide hybrid of the invention can be effectively used for the production of various immunosensors and immune chips.
Type
Patent
Appears in Collections:
3. Patents > Patents
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