YAP1 activation is associated with the progression and response to immunotherapy of non-muscle invasive bladder cancer

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YAP1 activation is associated with the progression and response to immunotherapy of non-muscle invasive bladder cancer
Seung Woo Baek; J Y Mun; In Hwan Jang; G E Yang; M S Jeong; Seon-Kyu Kim; J K Nam; In-Sun Chu; S H Leem
Bibliographic Citation
Ebiomedicine, vol. 81, pp. 104092-104092
Publication Year
Background: Despite the availability of several treatments for non-muscle-invasive bladder cancer (NMIBC), many patients are still not responsive to treatments, and the disease progresses. A new prognostic classifier can differentiate between treatment response and progression, and it could be used as a very important tool in patient decision-making regarding treatment options. In this study, we focused on the activation of Yes-associated protein 1 (YAP1), which is known to play a pivotal role in tumour progression and serves as a factor contributing to the mechanism of resistance to various relevant therapeutic agents. We further evaluated its potential as a novel prognostic agent. Methods: We identified YAP1-associated gene signatures based on UC3-siYAP1 cells (n=8) and NMIBC cohort (n=460). Cross-validation was performed using 5 independent bladder cancer patient cohorts (n=1006). We also experimentally validated the changes of gene expression levels representing each subgroup. Findings: The 976-gene signature based on YAP1-activation redefined three subgroups and had the benefits of Bacillus Calmette-Guerin (BCG) treatment in patients with NMIBC (hazard ratio 3.32, 95% CI 1.29-8.56, p = 0.01). The integrated analysis revealed that YAP1 activation was associated with the characterization of patients with high-risk NMIBC and the response to immunotherapy. Interpretation: This study suggests that YAP1 activation has an important prognostic effect on bladder cancer progression and might be useful in the selection of immunotherapy.
Non-muscle-invasive bladder cancer (NMIBC)YAP1PrognosisBacillus Calmette-Gu erin (BCG)Immunotherapy
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Aging Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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